Regulation of death receptor-mediated apoptosis pathways
Apoptosis or programmed cell death can be induced by a variety of stimuli including activation of death receptors. This subgroup of the TNF/NGF-receptor-superfamily activates caspases, a family of aspartyl-specific cysteine-proteases, which are the main executioners of apoptosis. Depending on the ce...
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| Veröffentlicht in: | International Journal of Biochemistry and Cell Biology 2000-11, Vol.32 (11), p.1123-1136 |
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| container_end_page | 1136 |
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| container_issue | 11 |
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| container_title | International Journal of Biochemistry and Cell Biology |
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| creator | Schmitz, Ingo Kirchhoff, Sabine Krammer, Peter H |
| description | Apoptosis or programmed cell death can be induced by a variety of stimuli including activation of death receptors. This subgroup of the TNF/NGF-receptor-superfamily activates caspases, a family of aspartyl-specific cysteine-proteases, which are the main executioners of apoptosis. Depending on the cell type, signalling pathways downstream of the death receptors can be modulated by different proteins such as Bcl-2, FLIPs, chaperones and kinases. Deregulation of apoptosis has been associated with diseases as cancer, autoimmunity and AIDS. Therefore, the identification of modulators of apoptosis has several therapeutic implications. |
| doi_str_mv | 10.1016/S1357-2725(00)00048-0 |
| format | Article |
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| identifier | ISSN: 1357-2725 |
| ispartof | International Journal of Biochemistry and Cell Biology, 2000-11, Vol.32 (11), p.1123-1136 |
| issn | 1357-2725 1878-5875 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Apoptosis Caspases Caspases - metabolism CD95 Death receptors fas Receptor - metabolism FLIP Humans Ligands Molecular Chaperones - metabolism Phosphotransferases - metabolism Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Receptors, Tumor Necrosis Factor - metabolism Signal Transduction |
| title | Regulation of death receptor-mediated apoptosis pathways |
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