FXR, a Bile Acid Receptor and Biological Sensor

Bile acid synthesis is a major pathway for cholesterol disposal and thus represents a potential therapeutic target pathway for the treatment of hypercholesterolemia. Recently, the nuclear farnesoid X receptor (FXR) was identified as a bile acid receptor and biological sensor for the regulation of bi...

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Veröffentlicht in:	Trends in Cardiovascular Medicine 2000, Vol.10 (1), p.30-35
Hauptverfasser:	Tu, Hua, Okamoto, Arthur Y, Shan, Bei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile - metabolism Bile Acids and Salts - metabolism Cholesterol - metabolism DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation - physiology Humans Ligands Receptors, Cell Surface - antagonists & inhibitors Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, Cytoplasmic and Nuclear Structure-Activity Relationship Transcription Factors - antagonists & inhibitors Transcription Factors - genetics Transcription Factors - metabolism
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