Tumor necrosis factor-alpha (TNF-alpha)-induced and interleukin-1 beta (IL-1 beta)-induced shedding of TNF receptors from gingival fibroblasts

Tumor necrosis factor-alpha (TNF-alpha) exerts its functions by binding two different receptors (TNFR55 and TNFR75). Both TNFR55 and TNFR75 exist in cell-associated and soluble forms. Soluble TNF receptors (sTNFR), sTNFR55 and sTNFR75, are proteolytically shed upon inflammatory stimuli and then modu...

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Veröffentlicht in:	Journal of interferon & cytokine research 2000-12, Vol.20 (12), p.1077-1082
Hauptverfasser:	Ohe, H, Takashiba, S, Naruishi, K, Chou, H H, Yamada, H, Nishimura, F, Arai, H, Murayama, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - metabolism Binding, Competitive Cells, Cultured Fibroblasts - drug effects Fibroblasts - metabolism Gingiva - drug effects Gingiva - metabolism Humans Immunohistochemistry Interleukin 1^b Interleukin-1 - pharmacology Iodine Radioisotopes Receptors, Tumor Necrosis Factor - metabolism Receptors, Tumor Necrosis Factor, Type I Receptors, Tumor Necrosis Factor, Type II tumor necrosis factor receptors Tumor Necrosis Factor-alpha - pharmacology
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