Induction of antigen-specific CD8+ T cells, T helper cells, and protective levels of antibody in humans by particle-mediated administration of a hepatitis B virus DNA vaccine

A DNA vaccine against the hepatitis B virus (HBV) was evaluated for safety and induction of immune responses in 12 healthy, hepatitis-naı̈ve human volunteers using the needle-free PowderJect™ system to deliver gold particles coated with DNA directly into cells of the skin. Three groups of four volun...

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Veröffentlicht in:	Vaccine 2000-11, Vol.19 (7), p.764-778
Hauptverfasser:	Roy, Michael J, Wu, Mary S, Barr, Lori James, Fuller, James T, Tussey, Lynda G, Speller, Sue, Culp, Jerilyn, Burkholder, Joseph K, Swain, William F, Dixon, Russell M, Widera, Georg, Vessey, Rupert, King, Abbi, Ogg, Graham, Gallimore, Awen, Haynes, Joel R, Heydenburg Fuller, Deborah
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biolistics Biological and medical sciences CD8 antigen CD8-Positive T-Lymphocytes - immunology Clinical trial DNA vaccine Epidemiology. Vaccinations Female General aspects Gold HBV Hepatitis B - immunology Hepatitis B - prevention & control Hepatitis B Antibodies - biosynthesis Hepatitis B Surface Antigens - immunology Hepatitis B Vaccines - administration & dosage Hepatitis B Vaccines - adverse effects hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - immunology histocompatibility antigen HLA Humans Infectious diseases Male Medical sciences Middle Aged Particle Size Plasmids - genetics Safety T-Lymphocytes, Helper-Inducer - immunology Vaccines, DNA - administration & dosage Vaccines, DNA - adverse effects
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