Acute protective effect of nimodipine and dimethyl sulfoxide against hypoxic and ischemic damage in brain slices

Nimodipine and dimethyl sulfoxide (DMSO) were tested (alone and in combination) regarding their ability to increase hypoxic tolerance of brain slices under ‘hypoxic’ (deprivation of oxygen) or ‘ischemic’ (hypoxia+withdrawal of glucose) conditions. Direct current (DC) and evoked potentials were recor...

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Veröffentlicht in:	Brain research 2000-12, Vol.887 (2), p.316-322
Hauptverfasser:	Greiner, Christoph, Schmidinger, Andrea, Hülsmann, Swen, Moskopp, Dag, Wölfer, Johannes, Köhling, Rüdiger, Speckmann, Erwin-Josef, Wassmann, Hansdetlef
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - drug effects Brain - physiology Brain - physiopathology Brain Ischemia - prevention & control Brain slice Dimethyl sulfoxide Dimethyl Sulfoxide - pharmacology Evoked Potentials - drug effects Guinea Pigs Hypoxia, Brain - prevention & control Hypoxia-Ischemia, Brain - physiopathology Hypoxia-Ischemia, Brain - prevention & control In Vitro Techniques Ischemia Medical sciences Membrane Potentials - drug effects Nerve Endings - drug effects Nerve Endings - physiology Neuropharmacology Neuroprotection Neuroprotective agent Nimodipine Nimodipine - pharmacology Pharmacology. Drug treatments Pyramidal Cells - drug effects Pyramidal Cells - physiology Reaction Time
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