Nosocomial outbreak of vancomycin-resistant Enterococcus faecium at a German University Pediatric Hospital
Nosocomial Infections caused by vancomycin–resistant enterococci (VRE) are an emerging threat to critically ill patients. At the University Hospital Eppendorf, VRE were isolated from 38 patients between August 1993 and April 1997, of whom 32 were hospitalized at the Department of Pediatrics. Pulsed-...
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| Veröffentlicht in: | International journal of hygiene and environmental health 2000-10, Vol.203 (2), p.147-152 |
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| container_title | International journal of hygiene and environmental health |
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| creator | Elsner, Holger-Andreas Sobottka, Ingo Feucht, Heinz-Hubert Harps, Egmont Haun, Christoph Mack, Dietrich Ganschow, Rainer Laufs, Rainer Kaulfers, Paul-Michael |
| description | Nosocomial Infections caused by vancomycin–resistant enterococci (VRE) are an emerging threat to critically ill patients. At the University Hospital Eppendorf, VRE were isolated from 38 patients between August 1993 and April 1997, of whom 32 were hospitalized at the Department of Pediatrics. Pulsed-field gel electrophoresis revealed that 26
Enterococcus faecium isolates from patients of the Department of Pediatrics were identical or closely related, and that isolates from three additional patients of the same department were possibly related. All of these isolates were of
vanA genotype. They were resistant to glycopeptides, ampicillin, ciprofloxacin, clindamycin, and erythromycin. Most isolates displayed high–level resistance to gentamicin, but all remained susceptible to quinupristin/dalfopristin. Implementation of stringent hand disinfection and environmental disinfection policies, as well as measures for patient isolation contained this first outbreak of VRE at a German Children's hospital, which emphasizes the importance of hygienic measures for the control of nosocomial spread of these organisms. |
| doi_str_mv | 10.1078/S1438-4639(04)70020-6 |
| format | Article |
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Enterococcus faecium isolates from patients of the Department of Pediatrics were identical or closely related, and that isolates from three additional patients of the same department were possibly related. All of these isolates were of
vanA genotype. They were resistant to glycopeptides, ampicillin, ciprofloxacin, clindamycin, and erythromycin. Most isolates displayed high–level resistance to gentamicin, but all remained susceptible to quinupristin/dalfopristin. Implementation of stringent hand disinfection and environmental disinfection policies, as well as measures for patient isolation contained this first outbreak of VRE at a German Children's hospital, which emphasizes the importance of hygienic measures for the control of nosocomial spread of these organisms.</description><identifier>ISSN: 1438-4639</identifier><identifier>EISSN: 1618-131X</identifier><identifier>DOI: 10.1078/S1438-4639(04)70020-6</identifier><identifier>PMID: 11109567</identifier><language>eng</language><publisher>Jena: Elsevier GmbH</publisher><subject>Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Biological and medical sciences ; Child, Preschool ; Cross Infection - epidemiology ; Cross Infection - prevention & control ; Disease Outbreaks ; DNA Primers ; Electrophoresis, Gel, Pulsed-Field ; Enterococcus faecium ; Enterococcus faecium - genetics ; Enterococcus faecium - isolation & purification ; Female ; Germany - epidemiology ; Gram-Positive Bacterial Infections - epidemiology ; Gram-Positive Bacterial Infections - prevention & control ; Hospitals, Pediatric ; Human bacterial diseases ; Humans ; Incidence ; Infant ; infection ; Infectious diseases ; liver transplantation ; Male ; Medical sciences ; Microbial Sensitivity Tests ; Middle Aged ; nosocomial outbreak ; pediatry ; peritonitis ; Polymerase Chain Reaction ; Vancomycin Resistance</subject><ispartof>International journal of hygiene and environmental health, 2000-10, Vol.203 (2), p.147-152</ispartof><rights>2000 Urban & Fischer Verlag</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-124c27b7befc92b2b20ce558173f77096ff4d09dc38d4b9ac9d54a12e3a96ef73</citedby><cites>FETCH-LOGICAL-c390t-124c27b7befc92b2b20ce558173f77096ff4d09dc38d4b9ac9d54a12e3a96ef73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1438463904700206$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1009108$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11109567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elsner, Holger-Andreas</creatorcontrib><creatorcontrib>Sobottka, Ingo</creatorcontrib><creatorcontrib>Feucht, Heinz-Hubert</creatorcontrib><creatorcontrib>Harps, Egmont</creatorcontrib><creatorcontrib>Haun, Christoph</creatorcontrib><creatorcontrib>Mack, Dietrich</creatorcontrib><creatorcontrib>Ganschow, Rainer</creatorcontrib><creatorcontrib>Laufs, Rainer</creatorcontrib><creatorcontrib>Kaulfers, Paul-Michael</creatorcontrib><title>Nosocomial outbreak of vancomycin-resistant Enterococcus faecium at a German University Pediatric Hospital</title><title>International journal of hygiene and environmental health</title><addtitle>Int J Hyg Environ Health</addtitle><description>Nosocomial Infections caused by vancomycin–resistant enterococci (VRE) are an emerging threat to critically ill patients. At the University Hospital Eppendorf, VRE were isolated from 38 patients between August 1993 and April 1997, of whom 32 were hospitalized at the Department of Pediatrics. Pulsed-field gel electrophoresis revealed that 26
Enterococcus faecium isolates from patients of the Department of Pediatrics were identical or closely related, and that isolates from three additional patients of the same department were possibly related. All of these isolates were of
vanA genotype. They were resistant to glycopeptides, ampicillin, ciprofloxacin, clindamycin, and erythromycin. Most isolates displayed high–level resistance to gentamicin, but all remained susceptible to quinupristin/dalfopristin. Implementation of stringent hand disinfection and environmental disinfection policies, as well as measures for patient isolation contained this first outbreak of VRE at a German Children's hospital, which emphasizes the importance of hygienic measures for the control of nosocomial spread of these organisms.</description><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Biological and medical sciences</subject><subject>Child, Preschool</subject><subject>Cross Infection - epidemiology</subject><subject>Cross Infection - prevention & control</subject><subject>Disease Outbreaks</subject><subject>DNA Primers</subject><subject>Electrophoresis, Gel, Pulsed-Field</subject><subject>Enterococcus faecium</subject><subject>Enterococcus faecium - genetics</subject><subject>Enterococcus faecium - isolation & purification</subject><subject>Female</subject><subject>Germany - epidemiology</subject><subject>Gram-Positive Bacterial Infections - epidemiology</subject><subject>Gram-Positive Bacterial Infections - prevention & control</subject><subject>Hospitals, Pediatric</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>infection</subject><subject>Infectious diseases</subject><subject>liver transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>nosocomial outbreak</subject><subject>pediatry</subject><subject>peritonitis</subject><subject>Polymerase Chain Reaction</subject><subject>Vancomycin Resistance</subject><issn>1438-4639</issn><issn>1618-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFrFTEQxxex2Fr9CEoOUvSwmmyym81JpNRWKFXQgrcwOzuB1N3NM8k-eN--ad8TvUkOCcPvPzP8UlWvBH8vuO4_fBdK9rXqpHnL1TvNecPr7kl1IjrR10KKn0_L-w9yXD1P6a4wgvfmWXUshOCm7fRJdXcTUsAwe5hYWPMQCX6x4NgWllLdoV_qSMmnDEtmF0umWGjENTEHhH6dGWQG7JLiDAu7XfyWYvJ5x77R6CFHj-wqpI3PML2ojhxMiV4e7tPq9vPFj_Or-vrr5ZfzT9c1SsNzLRqFjR70QA5NM5TDkdq2F1o6rbnpnFMjNyPKflSDATRjq0A0JMF05LQ8rc72fTcx_F4pZTv7hDRNsFBYk9WN6kzfywK2exBjSCmSs5voZ4g7K7h9kGwfJdsHg5Yr-yjZdiX3-jBgHWYa_6YOVgvw5gBAQphcLDJ9-qc7N-UjCvZxj1GxsfUUbUJPCxZzkTDbMfj_bHIPluCa_A</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>Elsner, Holger-Andreas</creator><creator>Sobottka, Ingo</creator><creator>Feucht, Heinz-Hubert</creator><creator>Harps, Egmont</creator><creator>Haun, Christoph</creator><creator>Mack, Dietrich</creator><creator>Ganschow, Rainer</creator><creator>Laufs, Rainer</creator><creator>Kaulfers, Paul-Michael</creator><general>Elsevier GmbH</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001001</creationdate><title>Nosocomial outbreak of vancomycin-resistant Enterococcus faecium at a German University Pediatric Hospital</title><author>Elsner, Holger-Andreas ; 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At the University Hospital Eppendorf, VRE were isolated from 38 patients between August 1993 and April 1997, of whom 32 were hospitalized at the Department of Pediatrics. Pulsed-field gel electrophoresis revealed that 26
Enterococcus faecium isolates from patients of the Department of Pediatrics were identical or closely related, and that isolates from three additional patients of the same department were possibly related. All of these isolates were of
vanA genotype. They were resistant to glycopeptides, ampicillin, ciprofloxacin, clindamycin, and erythromycin. Most isolates displayed high–level resistance to gentamicin, but all remained susceptible to quinupristin/dalfopristin. Implementation of stringent hand disinfection and environmental disinfection policies, as well as measures for patient isolation contained this first outbreak of VRE at a German Children's hospital, which emphasizes the importance of hygienic measures for the control of nosocomial spread of these organisms.</abstract><cop>Jena</cop><pub>Elsevier GmbH</pub><pmid>11109567</pmid><doi>10.1078/S1438-4639(04)70020-6</doi><tpages>6</tpages></addata></record> |
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| ispartof | International journal of hygiene and environmental health, 2000-10, Vol.203 (2), p.147-152 |
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| subjects | Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Child, Preschool Cross Infection - epidemiology Cross Infection - prevention & control Disease Outbreaks DNA Primers Electrophoresis, Gel, Pulsed-Field Enterococcus faecium Enterococcus faecium - genetics Enterococcus faecium - isolation & purification Female Germany - epidemiology Gram-Positive Bacterial Infections - epidemiology Gram-Positive Bacterial Infections - prevention & control Hospitals, Pediatric Human bacterial diseases Humans Incidence Infant infection Infectious diseases liver transplantation Male Medical sciences Microbial Sensitivity Tests Middle Aged nosocomial outbreak pediatry peritonitis Polymerase Chain Reaction Vancomycin Resistance |
| title | Nosocomial outbreak of vancomycin-resistant Enterococcus faecium at a German University Pediatric Hospital |
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