In various tumour cell lines the peptide bradykinin B(2) receptor antagonist, Hoe 140 (Icatibant), may act as mitogenic agonist

This study examined the mitogenic effects of bradykinin (BK, Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg), the peptide bradykinin B(2) receptor antagonist Hoe 140 (D-Arg(0)[Hyp(3)-Thi(6)-D-Tic(7)-Oic(8)]BK, and the orally active, nonpeptide B(2) receptor antagonist FR 173657 ((E)-3-(6-acetamido-3-pyridyl)-N...

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Veröffentlicht in:	British journal of pharmacology 2000-12, Vol.131 (8), p.1553-1560
Hauptverfasser:	Drube, S, Liebmann, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Bradykinin - analogs & derivatives Bradykinin - pharmacology Bradykinin Receptor Antagonists DNA - biosynthesis DNA - drug effects Dose-Response Relationship, Drug Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Flavonoids - pharmacology Humans Inositol Phosphates - metabolism Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Mitogens - pharmacology Quinolines - pharmacology Receptor, Bradykinin B2 Receptors, Bradykinin - agonists Receptors, Bradykinin - physiology Signal Transduction Tumor Cells, Cultured - cytology Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism
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