Characterization of metabolites of Celecoxib in rabbits by liquid chromatography/tandem mass spectrometry

The metabolism of the anti‐inflammatory drug Celecoxib in rabbits was characterized using liquid chromatography (LC)/tandem mass spectrometry (MS/MS) with precursor ion and constant neutral loss scans followed by product ion scans. After separation by on‐line liquid chromatography, the crude urine s...

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Veröffentlicht in:	Journal of mass spectrometry. 2000-11, Vol.35 (11), p.1259-1270
Hauptverfasser:	Zhang, Ji Y., Wang, YueFen, Dudkowski, Caroline, Yang, Dai-chang, Chang, Ming, Yuan, Jinhua, Paulson, Susan K., Breau, Alan P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Anti-Inflammatory Agents, Non-Steroidal - blood Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Anti-Inflammatory Agents, Non-Steroidal - urine Biological and medical sciences Celecoxib Chromatography, Liquid - methods drug metabolism Feces - chemistry Female General pharmacology Glucuronides - blood Glucuronides - chemistry Glucuronides - metabolism Glucuronides - urine Hydrogen-Ion Concentration liquid chromatography Mass Spectrometry - methods Medical sciences metabolite identification Molecular Structure Pharmacology. Drug treatments Pyrazoles Rabbits Reference Standards Stereoisomerism Sulfonamides - blood Sulfonamides - chemistry Sulfonamides - pharmacokinetics Sulfonamides - urine tandem mass spectrometry
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