Ghrelin strongly stimulates growth hormone (GH) release in humans
Ghrelin is a recently identified endogenous ligand for the GH secretagogue receptor and is involved in a novel system for regulating GH release. However, little is known about its GH-releasing activity and other endocrine effects in humans. To address this issue, we studied the GH, ACTH, cortisol, P...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2000-12, Vol.85 (12), p.4908-4911 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | TAKAYA, Kazuhiko ARIYASU, Hiroyuki OGAWA, Yoshihiro HOSODA, Kiminori AKAMIZU, Takashi KOJIMA, Masayasu KANGAWA, Kenji NAKAO, Kazuwa KANAMOTO, Naotetsu IWAKURA, Hiroshi YOSHIMOTO, Akihiro HARADA, Masaki MORI, Kiyoshi KOMATSU, Yasato USUI, Takeshi SHIMATSU, Akira |
| description | Ghrelin is a recently identified endogenous ligand for the GH secretagogue receptor and is involved in a novel system for regulating GH release. However, little is known about its GH-releasing activity and other endocrine effects in humans. To address this issue, we studied the GH, ACTH, cortisol, PRL, LH, FSH, and TSH responses to synthetic human ghrelin. In four normal male adults (28-37 yr), iv ghrelin administration released GH in a dose-dependent manner and 0.2, 1.0, and 5.0 microg/kg ghrelin produced 43.3 +/- 6.0, 81.5 +/- 12.7, and 107.0 +/- 10.7 ng/mL of the GH peak values at 30 min, respectively. ACTH, cortisol, and PRL levels were also elevated after ghrelin injection, while the lowest dose (0.2 microg/kg) resulted in only minimum peak values of these hormones (22.8 +/- 3.0 pg/mL, 9.4 +/- 1.9 microg/dL, and 4.6 +/- 0.6 ng/mL, respectively). There were no significant changes in LH, FSH, or TSH levels. This is the first study showing evidence that ghrelin strongly stimulates GH release in humans. |
| doi_str_mv | 10.1210/jc.85.12.4908 |
| format | Article |
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However, little is known about its GH-releasing activity and other endocrine effects in humans. To address this issue, we studied the GH, ACTH, cortisol, PRL, LH, FSH, and TSH responses to synthetic human ghrelin. In four normal male adults (28-37 yr), iv ghrelin administration released GH in a dose-dependent manner and 0.2, 1.0, and 5.0 microg/kg ghrelin produced 43.3 +/- 6.0, 81.5 +/- 12.7, and 107.0 +/- 10.7 ng/mL of the GH peak values at 30 min, respectively. ACTH, cortisol, and PRL levels were also elevated after ghrelin injection, while the lowest dose (0.2 microg/kg) resulted in only minimum peak values of these hormones (22.8 +/- 3.0 pg/mL, 9.4 +/- 1.9 microg/dL, and 4.6 +/- 0.6 ng/mL, respectively). There were no significant changes in LH, FSH, or TSH levels. This is the first study showing evidence that ghrelin strongly stimulates GH release in humans.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.85.12.4908</identifier><identifier>PMID: 11134161</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adrenocorticotropic Hormone - blood ; Adult ; Biological and medical sciences ; Dose-Response Relationship, Drug ; Follicle Stimulating Hormone - blood ; Fundamental and applied biological sciences. Psychology ; Ghrelin ; Hormones and neuropeptides. Regulation ; Human Growth Hormone - blood ; Human Growth Hormone - metabolism ; Humans ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; Luteinizing Hormone - blood ; Male ; Peptide Hormones ; Peptides - pharmacology ; Prolactin - blood ; Recombinant Proteins - pharmacology ; Time Factors ; Vertebrates: endocrinology</subject><ispartof>The journal of clinical endocrinology and metabolism, 2000-12, Vol.85 (12), p.4908-4911</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-af35ff92a57066b6b5e74a40f73061c94dcb4f38ca4dfb8a97f96c1a1dbf767a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=958323$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11134161$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TAKAYA, Kazuhiko</creatorcontrib><creatorcontrib>ARIYASU, Hiroyuki</creatorcontrib><creatorcontrib>OGAWA, Yoshihiro</creatorcontrib><creatorcontrib>HOSODA, Kiminori</creatorcontrib><creatorcontrib>AKAMIZU, Takashi</creatorcontrib><creatorcontrib>KOJIMA, Masayasu</creatorcontrib><creatorcontrib>KANGAWA, Kenji</creatorcontrib><creatorcontrib>NAKAO, Kazuwa</creatorcontrib><creatorcontrib>KANAMOTO, Naotetsu</creatorcontrib><creatorcontrib>IWAKURA, Hiroshi</creatorcontrib><creatorcontrib>YOSHIMOTO, Akihiro</creatorcontrib><creatorcontrib>HARADA, Masaki</creatorcontrib><creatorcontrib>MORI, Kiyoshi</creatorcontrib><creatorcontrib>KOMATSU, Yasato</creatorcontrib><creatorcontrib>USUI, Takeshi</creatorcontrib><creatorcontrib>SHIMATSU, Akira</creatorcontrib><title>Ghrelin strongly stimulates growth hormone (GH) release in humans</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Ghrelin is a recently identified endogenous ligand for the GH secretagogue receptor and is involved in a novel system for regulating GH release. However, little is known about its GH-releasing activity and other endocrine effects in humans. To address this issue, we studied the GH, ACTH, cortisol, PRL, LH, FSH, and TSH responses to synthetic human ghrelin. In four normal male adults (28-37 yr), iv ghrelin administration released GH in a dose-dependent manner and 0.2, 1.0, and 5.0 microg/kg ghrelin produced 43.3 +/- 6.0, 81.5 +/- 12.7, and 107.0 +/- 10.7 ng/mL of the GH peak values at 30 min, respectively. ACTH, cortisol, and PRL levels were also elevated after ghrelin injection, while the lowest dose (0.2 microg/kg) resulted in only minimum peak values of these hormones (22.8 +/- 3.0 pg/mL, 9.4 +/- 1.9 microg/dL, and 4.6 +/- 0.6 ng/mL, respectively). There were no significant changes in LH, FSH, or TSH levels. This is the first study showing evidence that ghrelin strongly stimulates GH release in humans.</description><subject>Adrenocorticotropic Hormone - blood</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Dose-Response Relationship, Drug</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ghrelin</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Human Growth Hormone - blood</subject><subject>Human Growth Hormone - metabolism</subject><subject>Humans</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>Peptide Hormones</subject><subject>Peptides - pharmacology</subject><subject>Prolactin - blood</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Time Factors</subject><subject>Vertebrates: endocrinology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9z0tLw0AUBeBBFFurS7cSEEQXqXMzr8yyFG2FghsFd-FmMtOk5FFnEkr_vQGrq3sW3zlwCbkFOocE6PPOzFMxxjnXND0jU9BcxAq0OidTShOItUq-JuQqhB2lwLlgl2QCAIyDhClZrEpv66qNQu-7dlsfx1A1Q429DdHWd4e-jMrON11ro8fV-ikatcVgo7FSDg224ZpcOKyDvTndGfl8fflYruPN--ptudjEhoHsY3RMOKcTFIpKmctcWMWRU6cYlWA0L0zOHUsN8sLlKWrltDSAUOROSYVsRh5-d_e--x5s6LOmCsbWNba2G0KmEi61YGKEdyc45I0tsr2vGvTH7O_pEdyfAAaDtfPYmir8Oy1SljD2A_NPZVI</recordid><startdate>20001201</startdate><enddate>20001201</enddate><creator>TAKAYA, Kazuhiko</creator><creator>ARIYASU, Hiroyuki</creator><creator>OGAWA, Yoshihiro</creator><creator>HOSODA, Kiminori</creator><creator>AKAMIZU, Takashi</creator><creator>KOJIMA, Masayasu</creator><creator>KANGAWA, Kenji</creator><creator>NAKAO, Kazuwa</creator><creator>KANAMOTO, Naotetsu</creator><creator>IWAKURA, Hiroshi</creator><creator>YOSHIMOTO, Akihiro</creator><creator>HARADA, Masaki</creator><creator>MORI, Kiyoshi</creator><creator>KOMATSU, Yasato</creator><creator>USUI, Takeshi</creator><creator>SHIMATSU, Akira</creator><general>Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20001201</creationdate><title>Ghrelin strongly stimulates growth hormone (GH) release in humans</title><author>TAKAYA, Kazuhiko ; ARIYASU, Hiroyuki ; OGAWA, Yoshihiro ; HOSODA, Kiminori ; AKAMIZU, Takashi ; KOJIMA, Masayasu ; KANGAWA, Kenji ; NAKAO, Kazuwa ; KANAMOTO, Naotetsu ; IWAKURA, Hiroshi ; YOSHIMOTO, Akihiro ; HARADA, Masaki ; MORI, Kiyoshi ; KOMATSU, Yasato ; USUI, Takeshi ; SHIMATSU, Akira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-af35ff92a57066b6b5e74a40f73061c94dcb4f38ca4dfb8a97f96c1a1dbf767a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adrenocorticotropic Hormone - blood</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Dose-Response Relationship, Drug</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ghrelin</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Human Growth Hormone - blood</topic><topic>Human Growth Hormone - metabolism</topic><topic>Humans</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>Peptide Hormones</topic><topic>Peptides - pharmacology</topic><topic>Prolactin - blood</topic><topic>Recombinant Proteins - pharmacology</topic><topic>Time Factors</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TAKAYA, Kazuhiko</creatorcontrib><creatorcontrib>ARIYASU, Hiroyuki</creatorcontrib><creatorcontrib>OGAWA, Yoshihiro</creatorcontrib><creatorcontrib>HOSODA, Kiminori</creatorcontrib><creatorcontrib>AKAMIZU, Takashi</creatorcontrib><creatorcontrib>KOJIMA, Masayasu</creatorcontrib><creatorcontrib>KANGAWA, Kenji</creatorcontrib><creatorcontrib>NAKAO, Kazuwa</creatorcontrib><creatorcontrib>KANAMOTO, Naotetsu</creatorcontrib><creatorcontrib>IWAKURA, Hiroshi</creatorcontrib><creatorcontrib>YOSHIMOTO, Akihiro</creatorcontrib><creatorcontrib>HARADA, Masaki</creatorcontrib><creatorcontrib>MORI, Kiyoshi</creatorcontrib><creatorcontrib>KOMATSU, Yasato</creatorcontrib><creatorcontrib>USUI, Takeshi</creatorcontrib><creatorcontrib>SHIMATSU, Akira</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TAKAYA, Kazuhiko</au><au>ARIYASU, Hiroyuki</au><au>OGAWA, Yoshihiro</au><au>HOSODA, Kiminori</au><au>AKAMIZU, Takashi</au><au>KOJIMA, Masayasu</au><au>KANGAWA, Kenji</au><au>NAKAO, Kazuwa</au><au>KANAMOTO, Naotetsu</au><au>IWAKURA, Hiroshi</au><au>YOSHIMOTO, Akihiro</au><au>HARADA, Masaki</au><au>MORI, Kiyoshi</au><au>KOMATSU, Yasato</au><au>USUI, Takeshi</au><au>SHIMATSU, Akira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ghrelin strongly stimulates growth hormone (GH) release in humans</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2000-12-01</date><risdate>2000</risdate><volume>85</volume><issue>12</issue><spage>4908</spage><epage>4911</epage><pages>4908-4911</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Ghrelin is a recently identified endogenous ligand for the GH secretagogue receptor and is involved in a novel system for regulating GH release. However, little is known about its GH-releasing activity and other endocrine effects in humans. To address this issue, we studied the GH, ACTH, cortisol, PRL, LH, FSH, and TSH responses to synthetic human ghrelin. In four normal male adults (28-37 yr), iv ghrelin administration released GH in a dose-dependent manner and 0.2, 1.0, and 5.0 microg/kg ghrelin produced 43.3 +/- 6.0, 81.5 +/- 12.7, and 107.0 +/- 10.7 ng/mL of the GH peak values at 30 min, respectively. ACTH, cortisol, and PRL levels were also elevated after ghrelin injection, while the lowest dose (0.2 microg/kg) resulted in only minimum peak values of these hormones (22.8 +/- 3.0 pg/mL, 9.4 +/- 1.9 microg/dL, and 4.6 +/- 0.6 ng/mL, respectively). There were no significant changes in LH, FSH, or TSH levels. This is the first study showing evidence that ghrelin strongly stimulates GH release in humans.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>11134161</pmid><doi>10.1210/jc.85.12.4908</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenocorticotropic Hormone - blood Adult Biological and medical sciences Dose-Response Relationship, Drug Follicle Stimulating Hormone - blood Fundamental and applied biological sciences. Psychology Ghrelin Hormones and neuropeptides. Regulation Human Growth Hormone - blood Human Growth Hormone - metabolism Humans Hypothalamus. Hypophysis. Epiphysis. Urophysis Luteinizing Hormone - blood Male Peptide Hormones Peptides - pharmacology Prolactin - blood Recombinant Proteins - pharmacology Time Factors Vertebrates: endocrinology |
| title | Ghrelin strongly stimulates growth hormone (GH) release in humans |
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