Anti-HIV Agents 45 and Antitumor Agents 205. Two New Sesquiterpenes, Leitneridanins A and B, and the Cytotoxic and Anti-HIV Principles from Leitneria floridana
Two new sesquiterpenes, leitneridanin A (1) and leitneridanin B (2), and seven known compounds, lirioresinol B, (-)-pinoresinal, (+)-lariciresinol, quassimarin (3), simalikalactone D (4), 1-methoxycanthinone (5), and 5-methoxycanthinone (6), were isolated from Leitneria floridana. Their structures w...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2000-12, Vol.63 (12), p.1712-1715 |
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| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 63 |
| creator | XU, Zhihong CHANG, Fang-Rong WANG, Hui-Kang KASHIWADA, Yoshiki MCPHAIL, Andrew T. BASTOW, Kenneth F. TACHIBANA, Yoko COSENTINO, Mark LEE, Kuo-Hsiung |
| description | Two new sesquiterpenes, leitneridanin A (1) and leitneridanin B (2), and seven known compounds, lirioresinol B, (-)-pinoresinal, (+)-lariciresinol, quassimarin (3), simalikalactone D (4), 1-methoxycanthinone (5), and 5-methoxycanthinone (6), were isolated from Leitneria floridana. Their structures were identified on the basis of spectral data. In vitro biological evaluation showed that 5 is a potent anti-HIV agent (EC(50) 0.26 g/mL; TI >39) and that 3-6 suppressed the growth of a panel of human tumor cell lines (KB, A-549, HCT-8, CAKI-1, MCF-7, and SK-MEL-2). Compounds 3 and 4 were significantly active, with ED(50) values in the range of 0.26-0.012 g/mL. |
| doi_str_mv | 10.1021/np000260u |
| format | Article |
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In vitro biological evaluation showed that 5 is a potent anti-HIV agent (EC(50) 0.26 g/mL; TI >39) and that 3-6 suppressed the growth of a panel of human tumor cell lines (KB, A-549, HCT-8, CAKI-1, MCF-7, and SK-MEL-2). Compounds 3 and 4 were significantly active, with ED(50) values in the range of 0.26-0.012 g/mL.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np000260u</identifier><identifier>PMID: 11141127</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Anti-HIV Agents - chemistry ; Anti-HIV Agents - isolation & purification ; Anti-HIV Agents - pharmacology ; Antineoplastic Agents, Phytogenic - chemistry ; Antineoplastic Agents, Phytogenic - isolation & purification ; Antineoplastic Agents, Phytogenic - pharmacology ; Drug Screening Assays, Antitumor ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; Rosales - chemistry ; Sesquiterpenes - chemistry ; Sesquiterpenes - isolation & purification ; Sesquiterpenes - pharmacology ; Spectrum Analysis ; Tumor Cells, Cultured</subject><ispartof>Journal of natural products (Washington, D.C.), 2000-12, Vol.63 (12), p.1712-1715</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11141127$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>XU, Zhihong</creatorcontrib><creatorcontrib>CHANG, Fang-Rong</creatorcontrib><creatorcontrib>WANG, Hui-Kang</creatorcontrib><creatorcontrib>KASHIWADA, Yoshiki</creatorcontrib><creatorcontrib>MCPHAIL, Andrew T.</creatorcontrib><creatorcontrib>BASTOW, Kenneth F.</creatorcontrib><creatorcontrib>TACHIBANA, Yoko</creatorcontrib><creatorcontrib>COSENTINO, Mark</creatorcontrib><creatorcontrib>LEE, Kuo-Hsiung</creatorcontrib><title>Anti-HIV Agents 45 and Antitumor Agents 205. Two New Sesquiterpenes, Leitneridanins A and B, and the Cytotoxic and Anti-HIV Principles from Leitneria floridana</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>Two new sesquiterpenes, leitneridanin A (1) and leitneridanin B (2), and seven known compounds, lirioresinol B, (-)-pinoresinal, (+)-lariciresinol, quassimarin (3), simalikalactone D (4), 1-methoxycanthinone (5), and 5-methoxycanthinone (6), were isolated from Leitneria floridana. Their structures were identified on the basis of spectral data. In vitro biological evaluation showed that 5 is a potent anti-HIV agent (EC(50) 0.26 g/mL; TI >39) and that 3-6 suppressed the growth of a panel of human tumor cell lines (KB, A-549, HCT-8, CAKI-1, MCF-7, and SK-MEL-2). 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Two New Sesquiterpenes, Leitneridanins A and B, and the Cytotoxic and Anti-HIV Principles from Leitneria floridana</title><author>XU, Zhihong ; CHANG, Fang-Rong ; WANG, Hui-Kang ; KASHIWADA, Yoshiki ; MCPHAIL, Andrew T. ; BASTOW, Kenneth F. ; TACHIBANA, Yoko ; COSENTINO, Mark ; LEE, Kuo-Hsiung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i245t-e185420120171caf4ee287bf2ea4d7c881a8d9ab57620280561845a798aa639d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Anti-HIV Agents - chemistry</topic><topic>Anti-HIV Agents - isolation & purification</topic><topic>Anti-HIV Agents - pharmacology</topic><topic>Antineoplastic Agents, Phytogenic - chemistry</topic><topic>Antineoplastic Agents, Phytogenic - isolation & purification</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Humans</topic><topic>Microbial Sensitivity Tests</topic><topic>Molecular Structure</topic><topic>Rosales - chemistry</topic><topic>Sesquiterpenes - chemistry</topic><topic>Sesquiterpenes - isolation & purification</topic><topic>Sesquiterpenes - pharmacology</topic><topic>Spectrum Analysis</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>XU, Zhihong</creatorcontrib><creatorcontrib>CHANG, Fang-Rong</creatorcontrib><creatorcontrib>WANG, Hui-Kang</creatorcontrib><creatorcontrib>KASHIWADA, Yoshiki</creatorcontrib><creatorcontrib>MCPHAIL, Andrew T.</creatorcontrib><creatorcontrib>BASTOW, Kenneth F.</creatorcontrib><creatorcontrib>TACHIBANA, Yoko</creatorcontrib><creatorcontrib>COSENTINO, Mark</creatorcontrib><creatorcontrib>LEE, Kuo-Hsiung</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>XU, Zhihong</au><au>CHANG, Fang-Rong</au><au>WANG, Hui-Kang</au><au>KASHIWADA, Yoshiki</au><au>MCPHAIL, Andrew T.</au><au>BASTOW, Kenneth F.</au><au>TACHIBANA, Yoko</au><au>COSENTINO, Mark</au><au>LEE, Kuo-Hsiung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-HIV Agents 45 and Antitumor Agents 205. Two New Sesquiterpenes, Leitneridanins A and B, and the Cytotoxic and Anti-HIV Principles from Leitneria floridana</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2000-12-01</date><risdate>2000</risdate><volume>63</volume><issue>12</issue><spage>1712</spage><epage>1715</epage><pages>1712-1715</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><abstract>Two new sesquiterpenes, leitneridanin A (1) and leitneridanin B (2), and seven known compounds, lirioresinol B, (-)-pinoresinal, (+)-lariciresinol, quassimarin (3), simalikalactone D (4), 1-methoxycanthinone (5), and 5-methoxycanthinone (6), were isolated from Leitneria floridana. Their structures were identified on the basis of spectral data. In vitro biological evaluation showed that 5 is a potent anti-HIV agent (EC(50) 0.26 g/mL; TI >39) and that 3-6 suppressed the growth of a panel of human tumor cell lines (KB, A-549, HCT-8, CAKI-1, MCF-7, and SK-MEL-2). Compounds 3 and 4 were significantly active, with ED(50) values in the range of 0.26-0.012 g/mL.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>11141127</pmid><doi>10.1021/np000260u</doi><tpages>4</tpages></addata></record> |
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| subjects | Anti-HIV Agents - chemistry Anti-HIV Agents - isolation & purification Anti-HIV Agents - pharmacology Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Drug Screening Assays, Antitumor Humans Microbial Sensitivity Tests Molecular Structure Rosales - chemistry Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Spectrum Analysis Tumor Cells, Cultured |
| title | Anti-HIV Agents 45 and Antitumor Agents 205. Two New Sesquiterpenes, Leitneridanins A and B, and the Cytotoxic and Anti-HIV Principles from Leitneria floridana |
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