Immunoenhancing properties of Plantago major leaf extract
Plantago major (PM), also known as plantain, is a weed found in temperate zones worldwide. PM leaves have been associated with various biological properties ranging from antiinflammatory, antimicrobial and antitumour to wound healing. However, its mechanism of action associated with boosting of the...
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| Veröffentlicht in: | Phytotherapy research 2000-12, Vol.14 (8), p.617-622 |
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| creator | Gomez-Flores, R. Calderon, C. L. Scheibel, L. W. Tamez-Guerra, P. Rodriguez-Padilla, C. Tamez-Guerra, R. Weber, R. J. |
| description | Plantago major (PM), also known as plantain, is a weed found in temperate zones worldwide. PM leaves have been associated with various biological properties ranging from antiinflammatory, antimicrobial and antitumour to wound healing. However, its mechanism of action associated with boosting of the immune function remains to be elucidated. We found that endotoxin‐free methanol extracts from PM leaves, at doses of 50, 100, 250, and 500 µg/mL, were associated with 4.4 ± 1, 6 ± 1, 12 ± 0.4, and 18 ± 0.4‐fold increases of nitric oxide (NO) production, and increased TNF‐α production (621 ± 31, 721 ± 36, 727 ± 36, and 1056 ± 52 U/mL, respectively) by rat peritoneal macrophages, in the absence of IFN‐γ or LPS. NO and TNF‐α production by untreated macrophages was negligible. In addition, PM extracts potentiated Con A‐induced lymphoproliferation (3‐ to 12‐fold increases) in a dose‐dependent fashion, compared with the effect of ConA alone. The regulation of immune parameters induced by plant extracts may be clinically relevant in numerous diseases including chronic viral infections, tuberculosis, AIDS and cancer. Copyright © 2000 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/1099-1573(200012)14:8<617::AID-PTR674>3.0.CO;2-N |
| format | Article |
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L. ; Scheibel, L. W. ; Tamez-Guerra, P. ; Rodriguez-Padilla, C. ; Tamez-Guerra, R. ; Weber, R. J.</creator><creatorcontrib>Gomez-Flores, R. ; Calderon, C. L. ; Scheibel, L. W. ; Tamez-Guerra, P. ; Rodriguez-Padilla, C. ; Tamez-Guerra, R. ; Weber, R. J.</creatorcontrib><description>Plantago major (PM), also known as plantain, is a weed found in temperate zones worldwide. PM leaves have been associated with various biological properties ranging from antiinflammatory, antimicrobial and antitumour to wound healing. However, its mechanism of action associated with boosting of the immune function remains to be elucidated. We found that endotoxin‐free methanol extracts from PM leaves, at doses of 50, 100, 250, and 500 µg/mL, were associated with 4.4 ± 1, 6 ± 1, 12 ± 0.4, and 18 ± 0.4‐fold increases of nitric oxide (NO) production, and increased TNF‐α production (621 ± 31, 721 ± 36, 727 ± 36, and 1056 ± 52 U/mL, respectively) by rat peritoneal macrophages, in the absence of IFN‐γ or LPS. NO and TNF‐α production by untreated macrophages was negligible. In addition, PM extracts potentiated Con A‐induced lymphoproliferation (3‐ to 12‐fold increases) in a dose‐dependent fashion, compared with the effect of ConA alone. The regulation of immune parameters induced by plant extracts may be clinically relevant in numerous diseases including chronic viral infections, tuberculosis, AIDS and cancer. Copyright © 2000 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/1099-1573(200012)14:8<617::AID-PTR674>3.0.CO;2-N</identifier><identifier>PMID: 11113999</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; Biological and medical sciences ; cell activation ; Ethylenediamines ; Formazans - chemistry ; Free Radical Scavengers - chemistry ; General pharmacology ; immunopotentiation ; leaf extract ; Lipopolysaccharides - chemistry ; Lymphocyte Activation - drug effects ; macrophage ; Macrophages, Peritoneal - drug effects ; Macrophages, Peritoneal - immunology ; Male ; Medical sciences ; Nitric Oxide - analysis ; Nitric Oxide - biosynthesis ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Extracts - chemistry ; Plant Extracts - immunology ; Plant Extracts - pharmacology ; Plant Leaves - chemistry ; Plant Leaves - immunology ; Plantago ; Plantago - chemistry ; Plantago - immunology ; Plants, Medicinal ; Rats ; Rats, Sprague-Dawley ; Scintillation Counting ; Sulfanilamides ; T cell ; Tetrazolium Salts - chemistry ; Thymus Gland - chemistry ; Tritium ; Tumor Necrosis Factor-alpha - analysis ; Tumor Necrosis Factor-alpha - biosynthesis</subject><ispartof>Phytotherapy research, 2000-12, Vol.14 (8), p.617-622</ispartof><rights>Copyright © 2000 John Wiley & Sons, Ltd.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F1099-1573%28200012%2914%3A8%3C617%3A%3AAID-PTR674%3E3.0.CO%3B2-N$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F1099-1573%28200012%2914%3A8%3C617%3A%3AAID-PTR674%3E3.0.CO%3B2-N$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=834588$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11113999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gomez-Flores, R.</creatorcontrib><creatorcontrib>Calderon, C. L.</creatorcontrib><creatorcontrib>Scheibel, L. W.</creatorcontrib><creatorcontrib>Tamez-Guerra, P.</creatorcontrib><creatorcontrib>Rodriguez-Padilla, C.</creatorcontrib><creatorcontrib>Tamez-Guerra, R.</creatorcontrib><creatorcontrib>Weber, R. J.</creatorcontrib><title>Immunoenhancing properties of Plantago major leaf extract</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>Plantago major (PM), also known as plantain, is a weed found in temperate zones worldwide. PM leaves have been associated with various biological properties ranging from antiinflammatory, antimicrobial and antitumour to wound healing. However, its mechanism of action associated with boosting of the immune function remains to be elucidated. We found that endotoxin‐free methanol extracts from PM leaves, at doses of 50, 100, 250, and 500 µg/mL, were associated with 4.4 ± 1, 6 ± 1, 12 ± 0.4, and 18 ± 0.4‐fold increases of nitric oxide (NO) production, and increased TNF‐α production (621 ± 31, 721 ± 36, 727 ± 36, and 1056 ± 52 U/mL, respectively) by rat peritoneal macrophages, in the absence of IFN‐γ or LPS. NO and TNF‐α production by untreated macrophages was negligible. In addition, PM extracts potentiated Con A‐induced lymphoproliferation (3‐ to 12‐fold increases) in a dose‐dependent fashion, compared with the effect of ConA alone. The regulation of immune parameters induced by plant extracts may be clinically relevant in numerous diseases including chronic viral infections, tuberculosis, AIDS and cancer. Copyright © 2000 John Wiley & Sons, Ltd.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>cell activation</subject><subject>Ethylenediamines</subject><subject>Formazans - chemistry</subject><subject>Free Radical Scavengers - chemistry</subject><subject>General pharmacology</subject><subject>immunopotentiation</subject><subject>leaf extract</subject><subject>Lipopolysaccharides - chemistry</subject><subject>Lymphocyte Activation - drug effects</subject><subject>macrophage</subject><subject>Macrophages, Peritoneal - drug effects</subject><subject>Macrophages, Peritoneal - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nitric Oxide - analysis</subject><subject>Nitric Oxide - biosynthesis</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - immunology</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves - chemistry</subject><subject>Plant Leaves - immunology</subject><subject>Plantago</subject><subject>Plantago - chemistry</subject><subject>Plantago - immunology</subject><subject>Plants, Medicinal</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Scintillation Counting</subject><subject>Sulfanilamides</subject><subject>T cell</subject><subject>Tetrazolium Salts - chemistry</subject><subject>Thymus Gland - chemistry</subject><subject>Tritium</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><subject>Tumor Necrosis Factor-alpha - biosynthesis</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFke1r1EAQhxdR7Fn9FyQgiH7Iua_Z3VOEemp7cNwVrdRvwyaZrWnzcmZz2P73bsh5zpeF4dmHmfkRYhidM0r5O0atTZnS4g2nlDL-lsmF-ZAxvVicrT6nl1ffMi0_ijmdL7fvebp5RGbHL4_JjFrFUsnMzxPyLITbqLCcyqfkhMUS1toZsaum2bcdtr9cW1TtTbLrux32Q4Uh6XxyWbt2cDdd0rjbrk9qdD7B-6F3xfCcPPGuDvji8J6SH1-_XC0v0vX2fLU8W6eVkFamRVkyrQoteZbLvCyEzEVGFZVYZsxrL2WZF-hz9MIq59HoEpXLMbcGM59ZcUpeT9442e89hgGaKhRYx8mw2wfQXGZGchPBlwdwnzdYwq6vGtc_wL9lI_DqALhQuNr348rhyBkhlRk13yfqT1Xjw38LhTESGO8L431higSYBAMxEoiJwJQICKCw3AKHzaETrelkrcKA90er6-8g00IruN6cw8VGrT_JawVC_AUu_ZJe</recordid><startdate>200012</startdate><enddate>200012</enddate><creator>Gomez-Flores, R.</creator><creator>Calderon, C. L.</creator><creator>Scheibel, L. W.</creator><creator>Tamez-Guerra, P.</creator><creator>Rodriguez-Padilla, C.</creator><creator>Tamez-Guerra, R.</creator><creator>Weber, R. J.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200012</creationdate><title>Immunoenhancing properties of Plantago major leaf extract</title><author>Gomez-Flores, R. ; Calderon, C. L. ; Scheibel, L. W. ; Tamez-Guerra, P. ; Rodriguez-Padilla, C. ; Tamez-Guerra, R. ; Weber, R. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3494-cdd175c7426b4bdc34b360504ed61f7f44dbcefbef395afe87de5abeb98e6f693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>cell activation</topic><topic>Ethylenediamines</topic><topic>Formazans - chemistry</topic><topic>Free Radical Scavengers - chemistry</topic><topic>General pharmacology</topic><topic>immunopotentiation</topic><topic>leaf extract</topic><topic>Lipopolysaccharides - chemistry</topic><topic>Lymphocyte Activation - drug effects</topic><topic>macrophage</topic><topic>Macrophages, Peritoneal - drug effects</topic><topic>Macrophages, Peritoneal - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nitric Oxide - analysis</topic><topic>Nitric Oxide - biosynthesis</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - immunology</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Leaves - chemistry</topic><topic>Plant Leaves - immunology</topic><topic>Plantago</topic><topic>Plantago - chemistry</topic><topic>Plantago - immunology</topic><topic>Plants, Medicinal</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Scintillation Counting</topic><topic>Sulfanilamides</topic><topic>T cell</topic><topic>Tetrazolium Salts - chemistry</topic><topic>Thymus Gland - chemistry</topic><topic>Tritium</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><topic>Tumor Necrosis Factor-alpha - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gomez-Flores, R.</creatorcontrib><creatorcontrib>Calderon, C. L.</creatorcontrib><creatorcontrib>Scheibel, L. 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J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoenhancing properties of Plantago major leaf extract</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2000-12</date><risdate>2000</risdate><volume>14</volume><issue>8</issue><spage>617</spage><epage>622</epage><pages>617-622</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>Plantago major (PM), also known as plantain, is a weed found in temperate zones worldwide. PM leaves have been associated with various biological properties ranging from antiinflammatory, antimicrobial and antitumour to wound healing. However, its mechanism of action associated with boosting of the immune function remains to be elucidated. We found that endotoxin‐free methanol extracts from PM leaves, at doses of 50, 100, 250, and 500 µg/mL, were associated with 4.4 ± 1, 6 ± 1, 12 ± 0.4, and 18 ± 0.4‐fold increases of nitric oxide (NO) production, and increased TNF‐α production (621 ± 31, 721 ± 36, 727 ± 36, and 1056 ± 52 U/mL, respectively) by rat peritoneal macrophages, in the absence of IFN‐γ or LPS. NO and TNF‐α production by untreated macrophages was negligible. In addition, PM extracts potentiated Con A‐induced lymphoproliferation (3‐ to 12‐fold increases) in a dose‐dependent fashion, compared with the effect of ConA alone. The regulation of immune parameters induced by plant extracts may be clinically relevant in numerous diseases including chronic viral infections, tuberculosis, AIDS and cancer. Copyright © 2000 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>11113999</pmid><doi>10.1002/1099-1573(200012)14:8<617::AID-PTR674>3.0.CO;2-N</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences cell activation Ethylenediamines Formazans - chemistry Free Radical Scavengers - chemistry General pharmacology immunopotentiation leaf extract Lipopolysaccharides - chemistry Lymphocyte Activation - drug effects macrophage Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - immunology Male Medical sciences Nitric Oxide - analysis Nitric Oxide - biosynthesis Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - immunology Plant Extracts - pharmacology Plant Leaves - chemistry Plant Leaves - immunology Plantago Plantago - chemistry Plantago - immunology Plants, Medicinal Rats Rats, Sprague-Dawley Scintillation Counting Sulfanilamides T cell Tetrazolium Salts - chemistry Thymus Gland - chemistry Tritium Tumor Necrosis Factor-alpha - analysis Tumor Necrosis Factor-alpha - biosynthesis |
| title | Immunoenhancing properties of Plantago major leaf extract |
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