Induction of Long-Term Protective Effects against Heterologous Challenge in SIVhu-Infected Macaques

A group of three rhesus macaques were inoculated with SIV isolated from a human (SIVhu) accidentally exposed and infected with SIVsm. Extensive sequence analyses of SIVhu obtained from the human and macaques following infection indicated the presence of truncated nef. Not only did nef fail to repair...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2000-12, Vol.278 (1), p.194-206
Hauptverfasser:	Villinger, François, Switzer, William M., Parekh, Bharat S., Otten, Ronald A., Adams, Debra, Shanmugam, Vedapuri, Bostik, Pavel, Mayne, Ann E., Chikkala, Nathaniel F., McClure, Harold M., Novembre, Francis, Yao, Qizhi, Heneine, Walid, Folks, Thomas M., Ansari, Aftab A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - blood CD4 antigen CD4 Lymphocyte Count Gene Products, nef - analysis Genes, nef HIV Infections - immunology HIV Infections - physiopathology HIV-2 - genetics HIV-2 - immunology HIV-2 - pathogenicity Humans Macaca Macaca mulatta nef gene nef Gene Products, Human Immunodeficiency Virus Open Reading Frames Reassortant Viruses - genetics Reassortant Viruses - immunology Reassortant Viruses - pathogenicity Simian Acquired Immunodeficiency Syndrome - blood Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - physiopathology Simian immunodeficiency virus Simian Immunodeficiency Virus - genetics Simian Immunodeficiency Virus - immunology Simian Immunodeficiency Virus - pathogenicity T-Lymphocytes, Cytotoxic - immunology Viral Load
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