Effects of Esophageal Acid Perfusion on Airway Hyperresponsiveness in Patients With Bronchial Asthma
The effects of gastroesophagealreflux on airway hyperresponsiveness in patients with bronchial asthmahave yet to be studied in significant detail. The purpose of thepresent study was to determine how esophageal acid perfusion couldchange airway responsiveness in patients with bronchial asthma. In se...
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| Veröffentlicht in: | Chest 2000-12, Vol.118 (6), p.1553-1556 |
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| creator | Wu, De-Nan Tanifuji, Yukio Kobayashi, Hitoshi Yamauchi, Kohei Kato, Chieko Suzuki, Kazuyuki Inoue, Hiroshi |
| description | The effects of gastroesophagealreflux on airway hyperresponsiveness in patients with bronchial asthmahave yet to be studied in significant detail. The purpose of thepresent study was to determine how esophageal acid perfusion couldchange airway responsiveness in patients with bronchial asthma.
In seven patients withbronchial asthma (mean ± SD age, 55.1 ± 6.4 years; four women andthree men), esophageal p, H was monitored by a p, H meter and airwayresponsiveness was evaluated by aerosol inhalation of methacholine, during esophageal perfusion through an esophageal tube filled witheither saline solution or 0.1N hydrochloric acid (HCl), the order ofwhich was selected at random, in 1-week intervals. Spirometry was alsoperformed during esophageal p, H monitoring.
Asignificant decrease in the geometric mean of airway sensitivity or theconcentration of methacholine causing a 35% fall in respiratoryconductance was observed during esophageal HCl perfusion compared withthat of saline solution perfusion (p < 0.01 or p < 0.003),although no significant changes were observed in vital capacity,FEV1, peak expiratory flow, respiratory resistance, orslope of respiratory conductance during the periods of saline solutionand HCl perfusion.
We concluded that anincrease in airway hyperresponsiveness was induced when HCl stimulatedthe esophagus in patients with bronchial asthma. These resultssuggest that esophageal reflux is one of the important factors thataggravate asthmatic status. |
| doi_str_mv | 10.1378/chest.118.6.1553 |
| format | Article |
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In seven patients withbronchial asthma (mean ± SD age, 55.1 ± 6.4 years; four women andthree men), esophageal p, H was monitored by a p, H meter and airwayresponsiveness was evaluated by aerosol inhalation of methacholine, during esophageal perfusion through an esophageal tube filled witheither saline solution or 0.1N hydrochloric acid (HCl), the order ofwhich was selected at random, in 1-week intervals. Spirometry was alsoperformed during esophageal p, H monitoring.
Asignificant decrease in the geometric mean of airway sensitivity or theconcentration of methacholine causing a 35% fall in respiratoryconductance was observed during esophageal HCl perfusion compared withthat of saline solution perfusion (p < 0.01 or p < 0.003),although no significant changes were observed in vital capacity,FEV1, peak expiratory flow, respiratory resistance, orslope of respiratory conductance during the periods of saline solutionand HCl perfusion.
We concluded that anincrease in airway hyperresponsiveness was induced when HCl stimulatedthe esophagus in patients with bronchial asthma. These resultssuggest that esophageal reflux is one of the important factors thataggravate asthmatic status.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.118.6.1553</identifier><identifier>PMID: 11115439</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Adult ; Aged ; airway hyperresponsiveness ; Asthma ; Asthma - complications ; Asthma - physiopathology ; Biological and medical sciences ; bronchial asthma ; Bronchial Hyperreactivity ; Bronchial Provocation Tests ; Catheters ; Chronic obstructive pulmonary disease, asthma ; esophageal acid perfusion ; Esophagus ; Esophagus - metabolism ; Female ; Forced Expiratory Volume ; Gastroesophageal reflux ; Gastroesophageal Reflux - complications ; Gastroesophageal Reflux - physiopathology ; Humans ; Hydrochloric acid ; Hydrochloric Acid - pharmacology ; Hydrogen-Ion Concentration ; Male ; Medical sciences ; Methacholine Chloride ; Middle Aged ; Peak Expiratory Flow Rate ; Pneumology ; Variance analysis ; Vital Capacity</subject><ispartof>Chest, 2000-12, Vol.118 (6), p.1553-1556</ispartof><rights>2000 The American College of Chest Physicians</rights><rights>2001 INIST-CNRS</rights><rights>Copyright American College of Chest Physicians Dec 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-b712faf2f04f5f1e1fdf637d49160dc11947c052a6280de83f109de9748c9ce23</citedby><cites>FETCH-LOGICAL-c442t-b712faf2f04f5f1e1fdf637d49160dc11947c052a6280de83f109de9748c9ce23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=845391$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11115439$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, De-Nan</creatorcontrib><creatorcontrib>Tanifuji, Yukio</creatorcontrib><creatorcontrib>Kobayashi, Hitoshi</creatorcontrib><creatorcontrib>Yamauchi, Kohei</creatorcontrib><creatorcontrib>Kato, Chieko</creatorcontrib><creatorcontrib>Suzuki, Kazuyuki</creatorcontrib><creatorcontrib>Inoue, Hiroshi</creatorcontrib><title>Effects of Esophageal Acid Perfusion on Airway Hyperresponsiveness in Patients With Bronchial Asthma</title><title>Chest</title><addtitle>Chest</addtitle><description>The effects of gastroesophagealreflux on airway hyperresponsiveness in patients with bronchial asthmahave yet to be studied in significant detail. The purpose of thepresent study was to determine how esophageal acid perfusion couldchange airway responsiveness in patients with bronchial asthma.
In seven patients withbronchial asthma (mean ± SD age, 55.1 ± 6.4 years; four women andthree men), esophageal p, H was monitored by a p, H meter and airwayresponsiveness was evaluated by aerosol inhalation of methacholine, during esophageal perfusion through an esophageal tube filled witheither saline solution or 0.1N hydrochloric acid (HCl), the order ofwhich was selected at random, in 1-week intervals. Spirometry was alsoperformed during esophageal p, H monitoring.
Asignificant decrease in the geometric mean of airway sensitivity or theconcentration of methacholine causing a 35% fall in respiratoryconductance was observed during esophageal HCl perfusion compared withthat of saline solution perfusion (p < 0.01 or p < 0.003),although no significant changes were observed in vital capacity,FEV1, peak expiratory flow, respiratory resistance, orslope of respiratory conductance during the periods of saline solutionand HCl perfusion.
We concluded that anincrease in airway hyperresponsiveness was induced when HCl stimulatedthe esophagus in patients with bronchial asthma. These resultssuggest that esophageal reflux is one of the important factors thataggravate asthmatic status.</description><subject>Adult</subject><subject>Aged</subject><subject>airway hyperresponsiveness</subject><subject>Asthma</subject><subject>Asthma - complications</subject><subject>Asthma - physiopathology</subject><subject>Biological and medical sciences</subject><subject>bronchial asthma</subject><subject>Bronchial Hyperreactivity</subject><subject>Bronchial Provocation Tests</subject><subject>Catheters</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>esophageal acid perfusion</subject><subject>Esophagus</subject><subject>Esophagus - metabolism</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Gastroesophageal reflux</subject><subject>Gastroesophageal Reflux - complications</subject><subject>Gastroesophageal Reflux - physiopathology</subject><subject>Humans</subject><subject>Hydrochloric acid</subject><subject>Hydrochloric Acid - pharmacology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methacholine Chloride</subject><subject>Middle Aged</subject><subject>Peak Expiratory Flow Rate</subject><subject>Pneumology</subject><subject>Variance analysis</subject><subject>Vital Capacity</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kd1rFDEUxYNY7Lr67pMEBd9mm4_59G1bVisU2gfFx5AmN52UmcmYO9Oy_73Z7qAoNATChXPOPfxCyDvONlxW9ZlpAacN5_Wm3PCikC_IijeSZ7LI5UuyYoyLTJaNOCWvEe9ZmnlTviKnPJ0kaVbE7pwDMyENju4wjK2-A93RrfGW3kB0M_ow0HS3Pj7qPb3cjxAj4BgG9A8wACL1A73Rk4chxfz0U0vPYxhM6w85OLW9fkNOnO4Q3i7vmvz4svt-cZldXX_9drG9ykyeiym7rbhw2gnHclc4DtxZV8rK5g0vmTWpe14ZVghdippZqKXjrLHQVHltGgNCrsmnY-4Yw685oVG9RwNdpwcIM6pK5GVZNDwJP_wnvA9zHFI3JRgruCwSxjVhR5GJATGCU2P0vY57xZk64FdP-FXCr0p1wJ8s75fc-bYH-9ew8E6Cj4tAo9Gdi3owHv_o6ryQT_WWza2_ax99BIW97roUKo87l7b_bP58tEDi--AhKjTpRwzYZDeTssE_X_s3C_2zLA</recordid><startdate>20001201</startdate><enddate>20001201</enddate><creator>Wu, De-Nan</creator><creator>Tanifuji, Yukio</creator><creator>Kobayashi, Hitoshi</creator><creator>Yamauchi, Kohei</creator><creator>Kato, Chieko</creator><creator>Suzuki, Kazuyuki</creator><creator>Inoue, Hiroshi</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20001201</creationdate><title>Effects of Esophageal Acid Perfusion on Airway Hyperresponsiveness in Patients With Bronchial Asthma</title><author>Wu, De-Nan ; Tanifuji, Yukio ; Kobayashi, Hitoshi ; Yamauchi, Kohei ; Kato, Chieko ; Suzuki, Kazuyuki ; Inoue, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-b712faf2f04f5f1e1fdf637d49160dc11947c052a6280de83f109de9748c9ce23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>airway hyperresponsiveness</topic><topic>Asthma</topic><topic>Asthma - complications</topic><topic>Asthma - physiopathology</topic><topic>Biological and medical sciences</topic><topic>bronchial asthma</topic><topic>Bronchial Hyperreactivity</topic><topic>Bronchial Provocation Tests</topic><topic>Catheters</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>esophageal acid perfusion</topic><topic>Esophagus</topic><topic>Esophagus - metabolism</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Gastroesophageal reflux</topic><topic>Gastroesophageal Reflux - complications</topic><topic>Gastroesophageal Reflux - physiopathology</topic><topic>Humans</topic><topic>Hydrochloric acid</topic><topic>Hydrochloric Acid - pharmacology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methacholine Chloride</topic><topic>Middle Aged</topic><topic>Peak Expiratory Flow Rate</topic><topic>Pneumology</topic><topic>Variance analysis</topic><topic>Vital Capacity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, De-Nan</creatorcontrib><creatorcontrib>Tanifuji, Yukio</creatorcontrib><creatorcontrib>Kobayashi, Hitoshi</creatorcontrib><creatorcontrib>Yamauchi, Kohei</creatorcontrib><creatorcontrib>Kato, Chieko</creatorcontrib><creatorcontrib>Suzuki, Kazuyuki</creatorcontrib><creatorcontrib>Inoue, Hiroshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, De-Nan</au><au>Tanifuji, Yukio</au><au>Kobayashi, Hitoshi</au><au>Yamauchi, Kohei</au><au>Kato, Chieko</au><au>Suzuki, Kazuyuki</au><au>Inoue, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Esophageal Acid Perfusion on Airway Hyperresponsiveness in Patients With Bronchial Asthma</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>2000-12-01</date><risdate>2000</risdate><volume>118</volume><issue>6</issue><spage>1553</spage><epage>1556</epage><pages>1553-1556</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>The effects of gastroesophagealreflux on airway hyperresponsiveness in patients with bronchial asthmahave yet to be studied in significant detail. The purpose of thepresent study was to determine how esophageal acid perfusion couldchange airway responsiveness in patients with bronchial asthma.
In seven patients withbronchial asthma (mean ± SD age, 55.1 ± 6.4 years; four women andthree men), esophageal p, H was monitored by a p, H meter and airwayresponsiveness was evaluated by aerosol inhalation of methacholine, during esophageal perfusion through an esophageal tube filled witheither saline solution or 0.1N hydrochloric acid (HCl), the order ofwhich was selected at random, in 1-week intervals. Spirometry was alsoperformed during esophageal p, H monitoring.
Asignificant decrease in the geometric mean of airway sensitivity or theconcentration of methacholine causing a 35% fall in respiratoryconductance was observed during esophageal HCl perfusion compared withthat of saline solution perfusion (p < 0.01 or p < 0.003),although no significant changes were observed in vital capacity,FEV1, peak expiratory flow, respiratory resistance, orslope of respiratory conductance during the periods of saline solutionand HCl perfusion.
We concluded that anincrease in airway hyperresponsiveness was induced when HCl stimulatedthe esophagus in patients with bronchial asthma. These resultssuggest that esophageal reflux is one of the important factors thataggravate asthmatic status.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>11115439</pmid><doi>10.1378/chest.118.6.1553</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Aged airway hyperresponsiveness Asthma Asthma - complications Asthma - physiopathology Biological and medical sciences bronchial asthma Bronchial Hyperreactivity Bronchial Provocation Tests Catheters Chronic obstructive pulmonary disease, asthma esophageal acid perfusion Esophagus Esophagus - metabolism Female Forced Expiratory Volume Gastroesophageal reflux Gastroesophageal Reflux - complications Gastroesophageal Reflux - physiopathology Humans Hydrochloric acid Hydrochloric Acid - pharmacology Hydrogen-Ion Concentration Male Medical sciences Methacholine Chloride Middle Aged Peak Expiratory Flow Rate Pneumology Variance analysis Vital Capacity |
| title | Effects of Esophageal Acid Perfusion on Airway Hyperresponsiveness in Patients With Bronchial Asthma |
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