Presentation, management and outcome of axillary recurrence from breast cancer
Background: The impact of axillary node dissection on breast cancer survival is unclear. Limited axillary surgery has been proposed but may increase regional recurrence rates. Optimal management for axillary recurrence is poorly understood. Methods: Axillary recurrences were initial treatment failur...
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| Veröffentlicht in: | The American journal of surgery 2000-10, Vol.180 (4), p.252-256 |
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| container_title | The American journal of surgery |
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| creator | Newman, Lisa A Hunt, Kelly K Buchholz, Thomas Kuerer, Henry M Vlastos, George Mirza, Nadeem Ames, Frederick C Ross, Merrick I Singletary, S.Eva |
| description | Background: The impact of axillary node dissection on breast cancer survival is unclear. Limited axillary surgery has been proposed but may increase regional recurrence rates. Optimal management for axillary recurrence is poorly understood.
Methods: Axillary recurrences were initial treatment failure sites in 44 of 4,255 breast cancer patients (1%) seen at M.D. Anderson Cancer Center, 1982 to 1992.
Results: Twenty-one patients (48%) had early stage disease (0, I, II) at diagnosis. With 70.8 months median follow-up, complete control of axillary recurrence was achieved in 31 patients (71%). Distant metastases developed in 50% and were more likely with uncontrolled axillary recurrences. Failure to receive multimodality therapy and failure to undergo surgery for the recurrence correlated with resistant axillary disease.
Conclusions: Axillary recurrence from breast cancer is uncommon but may follow any stage of disease. One half of affected patients develop distant metastases. Durable disease control is best achieved with multimodality therapy including a surgery component. |
| doi_str_mv | 10.1016/S0002-9610(00)00456-6 |
| format | Article |
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Methods: Axillary recurrences were initial treatment failure sites in 44 of 4,255 breast cancer patients (1%) seen at M.D. Anderson Cancer Center, 1982 to 1992.
Results: Twenty-one patients (48%) had early stage disease (0, I, II) at diagnosis. With 70.8 months median follow-up, complete control of axillary recurrence was achieved in 31 patients (71%). Distant metastases developed in 50% and were more likely with uncontrolled axillary recurrences. Failure to receive multimodality therapy and failure to undergo surgery for the recurrence correlated with resistant axillary disease.
Conclusions: Axillary recurrence from breast cancer is uncommon but may follow any stage of disease. One half of affected patients develop distant metastases. Durable disease control is best achieved with multimodality therapy including a surgery component.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/S0002-9610(00)00456-6</identifier><identifier>PMID: 11113430</identifier><identifier>CODEN: AJSUAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Axilla ; Biological and medical sciences ; Biopsy ; Breast cancer ; Breast Neoplasms - diagnosis ; Breast Neoplasms - pathology ; Breast Neoplasms - therapy ; Cancer therapies ; Chemotherapy ; Combined Modality Therapy ; Disease control ; Dissection ; Failure ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Lymphatic Metastasis ; Lymphatic system ; Lymphedema ; Mammary gland diseases ; Mastectomy ; Medical sciences ; Metastases ; Metastasis ; Middle Aged ; Neoplasm Recurrence, Local - diagnosis ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - therapy ; Neoplasm Staging ; Patients ; Radiation therapy ; Surgery ; Time Factors ; Treatment Outcome ; Tumors</subject><ispartof>The American journal of surgery, 2000-10, Vol.180 (4), p.252-256</ispartof><rights>2000 Excerpta Medica Inc.</rights><rights>2001 INIST-CNRS</rights><rights>2000. Excerpta Medica Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-4066d8f6ec75e3a85235fab73f2f1617851063ac3dc96113e896f5ecfcdaaf8f3</citedby><cites>FETCH-LOGICAL-c417t-4066d8f6ec75e3a85235fab73f2f1617851063ac3dc96113e896f5ecfcdaaf8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2847450953?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>309,310,314,777,781,786,787,3537,23911,23912,25121,27905,27906,45976,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=849146$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11113430$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Newman, Lisa A</creatorcontrib><creatorcontrib>Hunt, Kelly K</creatorcontrib><creatorcontrib>Buchholz, Thomas</creatorcontrib><creatorcontrib>Kuerer, Henry M</creatorcontrib><creatorcontrib>Vlastos, George</creatorcontrib><creatorcontrib>Mirza, Nadeem</creatorcontrib><creatorcontrib>Ames, Frederick C</creatorcontrib><creatorcontrib>Ross, Merrick I</creatorcontrib><creatorcontrib>Singletary, S.Eva</creatorcontrib><title>Presentation, management and outcome of axillary recurrence from breast cancer</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Background: The impact of axillary node dissection on breast cancer survival is unclear. Limited axillary surgery has been proposed but may increase regional recurrence rates. Optimal management for axillary recurrence is poorly understood.
Methods: Axillary recurrences were initial treatment failure sites in 44 of 4,255 breast cancer patients (1%) seen at M.D. Anderson Cancer Center, 1982 to 1992.
Results: Twenty-one patients (48%) had early stage disease (0, I, II) at diagnosis. With 70.8 months median follow-up, complete control of axillary recurrence was achieved in 31 patients (71%). Distant metastases developed in 50% and were more likely with uncontrolled axillary recurrences. Failure to receive multimodality therapy and failure to undergo surgery for the recurrence correlated with resistant axillary disease.
Conclusions: Axillary recurrence from breast cancer is uncommon but may follow any stage of disease. One half of affected patients develop distant metastases. Durable disease control is best achieved with multimodality therapy including a surgery component.</description><subject>Adult</subject><subject>Aged</subject><subject>Axilla</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - therapy</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Combined Modality Therapy</subject><subject>Disease control</subject><subject>Dissection</subject><subject>Failure</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Lymphatic system</subject><subject>Lymphedema</subject><subject>Mammary gland diseases</subject><subject>Mastectomy</subject><subject>Medical sciences</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - diagnosis</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - therapy</subject><subject>Neoplasm Staging</subject><subject>Patients</subject><subject>Radiation therapy</subject><subject>Surgery</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkF1r2zAUhsVoWdJsP2FFUCgt1JtkfVi-KiX0C0I32HYtFPmoKMRWJtml_feVl5CV3VQIhA7POXr1IPSFkq-UUPntJyGkLGpJyRkh54RwIQv5AU2pquqCKsUO0HSPTNBRSqt8pZSzj2hC82KckSl6-BEhQdeb3ofuAremM4_Q5gI2XYPD0NvQAg4Om2e_Xpv4giPYIUboLGAXQ4uXEUzqsTW5Ej-hQ2fWCT7vzhn6fXP9a35XLL7f3s-vFoXltOoLTqRslJNgKwHMKFEy4cyyYq50VNJKCUokM5Y1NsenDFQtnQDrbGOMU47N0Ol27iaGPwOkXrc-WcgJOwhD0lXJpahrkcGT_8BVGGKXs-lS8YoLkqFMiS1lY0gpgtOb6Nv8W02JHnXrv7r16FKTcWfdWua-4930YdlC869r5_fN8yZZs3YxW_JpzyleUz6OudxSkJU9eYg6WT8abny23esm-HeCvALPkpsg</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>Newman, Lisa A</creator><creator>Hunt, Kelly K</creator><creator>Buchholz, Thomas</creator><creator>Kuerer, Henry M</creator><creator>Vlastos, George</creator><creator>Mirza, Nadeem</creator><creator>Ames, Frederick C</creator><creator>Ross, Merrick I</creator><creator>Singletary, S.Eva</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20001001</creationdate><title>Presentation, management and outcome of axillary recurrence from breast cancer</title><author>Newman, Lisa A ; Hunt, Kelly K ; Buchholz, Thomas ; Kuerer, Henry M ; Vlastos, George ; Mirza, Nadeem ; Ames, Frederick C ; Ross, Merrick I ; Singletary, S.Eva</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-4066d8f6ec75e3a85235fab73f2f1617851063ac3dc96113e896f5ecfcdaaf8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Axilla</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - therapy</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Combined Modality Therapy</topic><topic>Disease control</topic><topic>Dissection</topic><topic>Failure</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Lymphatic system</topic><topic>Lymphedema</topic><topic>Mammary gland diseases</topic><topic>Mastectomy</topic><topic>Medical sciences</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - diagnosis</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Recurrence, Local - therapy</topic><topic>Neoplasm Staging</topic><topic>Patients</topic><topic>Radiation therapy</topic><topic>Surgery</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Newman, Lisa A</creatorcontrib><creatorcontrib>Hunt, Kelly K</creatorcontrib><creatorcontrib>Buchholz, Thomas</creatorcontrib><creatorcontrib>Kuerer, Henry M</creatorcontrib><creatorcontrib>Vlastos, George</creatorcontrib><creatorcontrib>Mirza, Nadeem</creatorcontrib><creatorcontrib>Ames, Frederick C</creatorcontrib><creatorcontrib>Ross, Merrick I</creatorcontrib><creatorcontrib>Singletary, S.Eva</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Newman, Lisa A</au><au>Hunt, Kelly K</au><au>Buchholz, Thomas</au><au>Kuerer, Henry M</au><au>Vlastos, George</au><au>Mirza, Nadeem</au><au>Ames, Frederick C</au><au>Ross, Merrick I</au><au>Singletary, S.Eva</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Presentation, management and outcome of axillary recurrence from breast cancer</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>180</volume><issue>4</issue><spage>252</spage><epage>256</epage><pages>252-256</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><coden>AJSUAB</coden><abstract>Background: The impact of axillary node dissection on breast cancer survival is unclear. Limited axillary surgery has been proposed but may increase regional recurrence rates. Optimal management for axillary recurrence is poorly understood.
Methods: Axillary recurrences were initial treatment failure sites in 44 of 4,255 breast cancer patients (1%) seen at M.D. Anderson Cancer Center, 1982 to 1992.
Results: Twenty-one patients (48%) had early stage disease (0, I, II) at diagnosis. With 70.8 months median follow-up, complete control of axillary recurrence was achieved in 31 patients (71%). Distant metastases developed in 50% and were more likely with uncontrolled axillary recurrences. Failure to receive multimodality therapy and failure to undergo surgery for the recurrence correlated with resistant axillary disease.
Conclusions: Axillary recurrence from breast cancer is uncommon but may follow any stage of disease. One half of affected patients develop distant metastases. Durable disease control is best achieved with multimodality therapy including a surgery component.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11113430</pmid><doi>10.1016/S0002-9610(00)00456-6</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Axilla Biological and medical sciences Biopsy Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - pathology Breast Neoplasms - therapy Cancer therapies Chemotherapy Combined Modality Therapy Disease control Dissection Failure Female Gynecology. Andrology. Obstetrics Humans Lymphatic Metastasis Lymphatic system Lymphedema Mammary gland diseases Mastectomy Medical sciences Metastases Metastasis Middle Aged Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - therapy Neoplasm Staging Patients Radiation therapy Surgery Time Factors Treatment Outcome Tumors |
| title | Presentation, management and outcome of axillary recurrence from breast cancer |
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