A blood-tumor barrier limits gene transfer to experimental liver cancer: the effect of vasoactive compounds

We have evaluated gene transfer efficiency to tumor nodules in diethylnitrosoamine (DENA)-induced hepatocellular carcinoma (HCC) in rats using adenoviral vectors administered by three different routes: intraportal, intra-arterial and intratumoral injection. Our results showed that intraportal infusi...

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Veröffentlicht in:	Gene therapy 2000-11, Vol.7 (21), p.1824-1832
Hauptverfasser:	BILBAO, R, BUSTOS, M, ALZUGUREN, P, PAJARES, M. J, DROZDZIK, M, QIAN, C, PRIETO, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - analysis Adenoviridae - genetics Adenovirus Angiotensin Angiotensin II Angiotensin II - therapeutic use Animals Biological and medical sciences Biotechnology Diethylnitrosamine Expression vectors Extracellular matrix Extracellular Matrix - chemistry Fibronectin Fibronectins - analysis Fundamental and applied biological sciences. Psychology Gene Expression Gene therapy Genetic Therapy - methods Genetic Vectors - administration & dosage Health. Pharmaceutical industry Hepatocellular carcinoma Histamine Immunohistochemistry Industrial applications and implications. Economical aspects Injection Injections, Intra-Arterial Lac Operon Laminin Laminin - analysis Liver cancer Liver Neoplasms, Experimental - pathology Liver Neoplasms, Experimental - therapy Microspheres Nitric oxide Nitroglycerin Nitroglycerin - therapeutic use Nodules Portal System Rats Rats, Wistar Smooth muscle Starch - therapeutic use Transduction Transfection - methods Tumor cells Tumors Vasoactive agents Vasodilator Agents - therapeutic use
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