Induction of Differentiation and Apoptosis— A Possible Strategy in the Treatment of Adult Acute Myelogenous Leukemia

A differentiation block with accumulation of immature myeloid cells characterizes acute myelogenous leukemia (AML). However, native AML cells often show some morphological signs of differentiation that allow a classification into different subsets, and further differentiation may be induced by expos...

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Veröffentlicht in:	The oncologist (Dayton, Ohio) Ohio), 2000-12, Vol.5 (6), p.454-462
Hauptverfasser:	Bruserud, Øystein, Gjertsen, Bjørn Tore, Huang, Tien‐sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myelogenous leukemia Adult Apoptosis Apoptosis - drug effects Cell Differentiation - drug effects Differentiation Genes, Tumor Suppressor Humans Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - pathology Leukemia, Promyelocytic, Acute - drug therapy Prognosis Proto-Oncogene Proteins c-bcl-2 - analysis Tretinoin - therapeutic use
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