Human Uroporphyrinogen-III Synthase: Genomic Organization, Alternative Promoters, and Erythroid-Specific Expression

Uroporphyrinogen-III (URO) synthase is the heme biosynthetic enzyme defective in congenital erythropoietic porphyria. The ∼34-kb human URO-synthase gene (UROS) was isolated, and its organization and tissue-specific expression were determined. The gene had two promoters that generated housekeeping an...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 2000-12, Vol.70 (2), p.223-231
Hauptverfasser:	Aizencang, Gerardo, Solis, Constanza, Bishop, David F., Warner, Cecilia, Desnick, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences DNA Erythrocytes - enzymology Fundamental and applied biological sciences. Psychology Genes. Genome hemin Humans Molecular and cellular biology Molecular genetics Molecular Sequence Data Promoter Regions, Genetic RNA, Messenger - genetics Sequence Homology, Nucleic Acid Uroporphyrinogen III Synthetase - genetics UROS gene
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