Investigation of the mechanism of the interaction of tubulin with derivatives of 2-styrylquinazolin-4(3H)-one

A new class of antimitotic agents, derivatives of 2-styrylquinazolin-4(3H)-one (SQZ), was recently described [J. Med. Chem. 33:1721-1728 (1990)]. Because they appeared to interact at a new ligand binding site on tubulin, we attempted to determine their mechanism of action as inhibitors of tubulin po...

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Veröffentlicht in:	Molecular pharmacology 1991-11, Vol.40 (5), p.827-832
Hauptverfasser:	Lin, C M, Kang, G J, Roach, M C, Jiang, J B, Hesson, D P, Luduena, R F, Hamel, E
Format:	Artikel
Sprache:	eng
Schlagworte:	2-styrylquinazolin-4(3H)-one Antineoplastic agents Antineoplastic Agents - metabolism Binding Sites Biological and medical sciences Colchicine - metabolism effects on General aspects Guanosine Triphosphate - metabolism Medical sciences microtubules Pharmacology. Drug treatments polymerization Quinazolines - metabolism Styrenes - metabolism Tropolone - analogs & derivatives Tropolone - metabolism tubulin Tubulin - metabolism
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