Urokinase Stimulates Human Vascular Smooth Muscle Cell Migration via a Phosphatidylinositol 3-Kinase-Tyk2 Interaction

Janus kinases Jak1 and Tyk2 play an important role in urokinase-type plasminogen activator (uPA)-dependent signaling. We have recently demonstrated that both kinases are associated with the uPA receptor (uPAR) and mediate uPA-induced activation of signal transducers and activators of transcription (...

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Veröffentlicht in:	The Journal of biological chemistry 2000-12, Vol.275 (50), p.39466-39473
Hauptverfasser:	Kusch, Angelika, Tkachuk, Sergey, Haller, Hermann, Dietz, Rainer, Gulba, Dietrich C., Lipp, Martin, Dumler, Inna
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Blotting, Northern Cell Movement Cells, Cultured Chemotaxis Chromones - pharmacology Cytoskeleton Enzyme Activation Enzyme Inhibitors - pharmacology Genes, Dominant Glutathione Transferase - metabolism Humans Microscopy, Fluorescence Microscopy, Video Morpholines - pharmacology Muscle, Smooth, Vascular - cytology Phosphatidylinositol 3-Kinases - metabolism Precipitin Tests Protein Binding Protein-Tyrosine Kinases Proteins - genetics Proteins - metabolism Recombinant Fusion Proteins - metabolism RNA - metabolism Signal Transduction src Homology Domains Time Factors Transcription, Genetic TYK2 Kinase Tyrosine - metabolism Urokinase-Type Plasminogen Activator - metabolism Wortmannin
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