Isoprenaline-induced increase in mRNA levels of inhibitory G-protein α-subunits in rat heart

Long-term beta-adrenergic stimulation has been shown to desensitize the beta-adrenoceptor/adenylyl cyclase signalling pathway at both the receptor and the G-protein level. To further elucidate the cellular mechanism of G-protein regulation we investigated the influence of prolonged infusion of isopr...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 1991-06, Vol.343 (6), p.609-615
Hauptverfasser:	ESCHENHAGEN, T, MENDE, U, NOSE, M, SCHMITZ, W, SCHOLZ, H, WARNHOLTZ, A, WUÊSTEL, J.-M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Biological and medical sciences Blotting, Northern Cardiomegaly Catecholaminergic system GTP-Binding Proteins - genetics Heart Diseases - etiology Heart Rate - drug effects Heart Rate - physiology Isoproterenol - administration & dosage Isoproterenol - pharmacology Male Medical sciences Myocardium - metabolism Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Nucleic Acid Hybridization Pharmacology. Drug treatments Propranolol - pharmacology Rats Rats, Inbred Strains RNA, Messenger - genetics RNA, Messenger - metabolism Stimulation, Chemical Triiodothyronine - pharmacology
Online-Zugang:	Volltext
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