Detection of the association between a deletion polymorphism in the gene encoding angiotensin I-converting enzyme and advanced diabetic retinopathy
We investigated the relationship between advanced diabetic retinopathy (ADR) and an angiotensin-converting enzyme (ACE) gene polymorphism in subjects with type 2 diabetes and ADR, pre-proliferative (PrePDR) or proliferative diabetic retinopathy (PDR) without overt nephropathy. Polymerase chain react...
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| Veröffentlicht in: | Diabetes research and clinical practice 2000-12, Vol.50 (3), p.195-202 |
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| creator | Matsumoto, A Iwashima, Y Abiko, A Morikawa, A Sekiguchi, M Eto, M Makino, I |
| description | We investigated the relationship between advanced diabetic retinopathy (ADR) and an angiotensin-converting enzyme (ACE) gene polymorphism in subjects with type 2 diabetes and ADR, pre-proliferative (PrePDR) or proliferative diabetic retinopathy (PDR) without overt nephropathy. Polymerase chain reactions were used to detect insertion/deletion (I/D) polymorphisms of the ACE gene. There was no difference in the frequency of II, ID, or DD genotypes, or of I and D alleles among subjects with type 2 diabetes without diabetic retinopathy (NDR) or with simple diabetic retinopathy (SDR) and non-diabetic controls. There was also no difference in the frequency of ACE genotypes among subjects with type 2 diabetes with NDR, or SDR and ADR. However, the frequency of the ACE DD genotype in ADR was significantly higher than that in controls (
χ
2=6.64,
P=0.036). On the other hand, the frequency of the D allele in ADR was significantly higher than that in controls (
χ
2=6.33,
P=0.012), NDR (
χ
2=4.18,
P=0.041) and SDR (
χ
2=4.89,
P=0.027), respectively. These results indicate a significant relationship between the presence of the D allele polymorphism in the ACE gene and ADR in Japanese subjects with type 2 diabetes and no overt nephropathy. |
| doi_str_mv | 10.1016/S0168-8227(00)00194-7 |
| format | Article |
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χ
2=6.64,
P=0.036). On the other hand, the frequency of the D allele in ADR was significantly higher than that in controls (
χ
2=6.33,
P=0.012), NDR (
χ
2=4.18,
P=0.041) and SDR (
χ
2=4.89,
P=0.027), respectively. These results indicate a significant relationship between the presence of the D allele polymorphism in the ACE gene and ADR in Japanese subjects with type 2 diabetes and no overt nephropathy.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/S0168-8227(00)00194-7</identifier><identifier>PMID: 11106834</identifier><identifier>CODEN: DRCPE9</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Albuminuria ; Angiotensin-converting enzyme ; Associated diseases and complications ; Biological and medical sciences ; Blood Pressure ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - enzymology ; Diabetes Mellitus, Type 2 - genetics ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes. Impaired glucose tolerance ; Diabetic Retinopathy - enzymology ; Diabetic Retinopathy - genetics ; Diabetic Retinopathy - physiopathology ; Disease Progression ; DNA Transposable Elements ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Female ; Gene polymorphism ; Genotype ; Humans ; Male ; Medical sciences ; Middle Aged ; Nephropathy ; Peptidyl-Dipeptidase A - genetics ; Peptidyl-Dipeptidase A - metabolism ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Proliferative retinopathy ; Reference Values ; Sequence Deletion</subject><ispartof>Diabetes research and clinical practice, 2000-12, Vol.50 (3), p.195-202</ispartof><rights>2000 Elsevier Science Ireland Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-34f3c4b63e5506f5fa4f3a62d34b5a4ec1807d8e65922ed1536026e89f6535493</citedby><cites>FETCH-LOGICAL-c389t-34f3c4b63e5506f5fa4f3a62d34b5a4ec1807d8e65922ed1536026e89f6535493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0168-8227(00)00194-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=814395$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11106834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsumoto, A</creatorcontrib><creatorcontrib>Iwashima, Y</creatorcontrib><creatorcontrib>Abiko, A</creatorcontrib><creatorcontrib>Morikawa, A</creatorcontrib><creatorcontrib>Sekiguchi, M</creatorcontrib><creatorcontrib>Eto, M</creatorcontrib><creatorcontrib>Makino, I</creatorcontrib><title>Detection of the association between a deletion polymorphism in the gene encoding angiotensin I-converting enzyme and advanced diabetic retinopathy</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>We investigated the relationship between advanced diabetic retinopathy (ADR) and an angiotensin-converting enzyme (ACE) gene polymorphism in subjects with type 2 diabetes and ADR, pre-proliferative (PrePDR) or proliferative diabetic retinopathy (PDR) without overt nephropathy. Polymerase chain reactions were used to detect insertion/deletion (I/D) polymorphisms of the ACE gene. There was no difference in the frequency of II, ID, or DD genotypes, or of I and D alleles among subjects with type 2 diabetes without diabetic retinopathy (NDR) or with simple diabetic retinopathy (SDR) and non-diabetic controls. There was also no difference in the frequency of ACE genotypes among subjects with type 2 diabetes with NDR, or SDR and ADR. However, the frequency of the ACE DD genotype in ADR was significantly higher than that in controls (
χ
2=6.64,
P=0.036). On the other hand, the frequency of the D allele in ADR was significantly higher than that in controls (
χ
2=6.33,
P=0.012), NDR (
χ
2=4.18,
P=0.041) and SDR (
χ
2=4.89,
P=0.027), respectively. These results indicate a significant relationship between the presence of the D allele polymorphism in the ACE gene and ADR in Japanese subjects with type 2 diabetes and no overt nephropathy.</description><subject>Albuminuria</subject><subject>Angiotensin-converting enzyme</subject><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - enzymology</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic Retinopathy - enzymology</subject><subject>Diabetic Retinopathy - genetics</subject><subject>Diabetic Retinopathy - physiopathology</subject><subject>Disease Progression</subject><subject>DNA Transposable Elements</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephropathy</subject><subject>Peptidyl-Dipeptidase A - genetics</subject><subject>Peptidyl-Dipeptidase A - metabolism</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Proliferative retinopathy</subject><subject>Reference Values</subject><subject>Sequence Deletion</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc-KFDEQxoMo7uzqIygBQfTQmnT-dPoksq66sOBBPYdMUj0T6U7aJDMyvoYvbKZnWI9eKvDVr1LF9yH0jJI3lFD59mstqlFt270i5DUhtOdN9wCtqOraRX6IVvfIBbrM-QchRDIuHqMLSimRivEV-vMBCtjiY8BxwGUL2OQcrTeLtIbyCyBggx2MsEhzHA9TTPPW5wn7sIxsIACGYKPzYYNN2PhYIOTavW1sDHtI5diA8Psw1QXBYeP2Jlhw2HlTl3iLU60hzqZsD0_Qo8GMGZ6e3yv0_ePNt-vPzd2XT7fX7-8ay1RfGsYHZvlaMhCCyEEMpgpGto7xtTAcLFWkcwqk6NsWHBVMklaC6gcpmOA9u0IvT__OKf7cQS568tnCOJoAcZd113KhOkIrKE6gTTHnBIOek59MOmhK9DENvaShj1ZrQvSShu7q3PPzgt16Avdv6mx_BV6cAZOtGYdUTfH5nlOUs15U6t2JgmrG3kPS2Xo42udTzU676P9zyF_g8aje</recordid><startdate>20001201</startdate><enddate>20001201</enddate><creator>Matsumoto, A</creator><creator>Iwashima, Y</creator><creator>Abiko, A</creator><creator>Morikawa, A</creator><creator>Sekiguchi, M</creator><creator>Eto, M</creator><creator>Makino, I</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001201</creationdate><title>Detection of the association between a deletion polymorphism in the gene encoding angiotensin I-converting enzyme and advanced diabetic retinopathy</title><author>Matsumoto, A ; Iwashima, Y ; Abiko, A ; Morikawa, A ; Sekiguchi, M ; Eto, M ; Makino, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-34f3c4b63e5506f5fa4f3a62d34b5a4ec1807d8e65922ed1536026e89f6535493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Albuminuria</topic><topic>Angiotensin-converting enzyme</topic><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - enzymology</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetic Retinopathy - enzymology</topic><topic>Diabetic Retinopathy - genetics</topic><topic>Diabetic Retinopathy - physiopathology</topic><topic>Disease Progression</topic><topic>DNA Transposable Elements</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephropathy</topic><topic>Peptidyl-Dipeptidase A - genetics</topic><topic>Peptidyl-Dipeptidase A - metabolism</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Proliferative retinopathy</topic><topic>Reference Values</topic><topic>Sequence Deletion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsumoto, A</creatorcontrib><creatorcontrib>Iwashima, Y</creatorcontrib><creatorcontrib>Abiko, A</creatorcontrib><creatorcontrib>Morikawa, A</creatorcontrib><creatorcontrib>Sekiguchi, M</creatorcontrib><creatorcontrib>Eto, M</creatorcontrib><creatorcontrib>Makino, I</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsumoto, A</au><au>Iwashima, Y</au><au>Abiko, A</au><au>Morikawa, A</au><au>Sekiguchi, M</au><au>Eto, M</au><au>Makino, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of the association between a deletion polymorphism in the gene encoding angiotensin I-converting enzyme and advanced diabetic retinopathy</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2000-12-01</date><risdate>2000</risdate><volume>50</volume><issue>3</issue><spage>195</spage><epage>202</epage><pages>195-202</pages><issn>0168-8227</issn><eissn>1872-8227</eissn><coden>DRCPE9</coden><abstract>We investigated the relationship between advanced diabetic retinopathy (ADR) and an angiotensin-converting enzyme (ACE) gene polymorphism in subjects with type 2 diabetes and ADR, pre-proliferative (PrePDR) or proliferative diabetic retinopathy (PDR) without overt nephropathy. Polymerase chain reactions were used to detect insertion/deletion (I/D) polymorphisms of the ACE gene. There was no difference in the frequency of II, ID, or DD genotypes, or of I and D alleles among subjects with type 2 diabetes without diabetic retinopathy (NDR) or with simple diabetic retinopathy (SDR) and non-diabetic controls. There was also no difference in the frequency of ACE genotypes among subjects with type 2 diabetes with NDR, or SDR and ADR. However, the frequency of the ACE DD genotype in ADR was significantly higher than that in controls (
χ
2=6.64,
P=0.036). On the other hand, the frequency of the D allele in ADR was significantly higher than that in controls (
χ
2=6.33,
P=0.012), NDR (
χ
2=4.18,
P=0.041) and SDR (
χ
2=4.89,
P=0.027), respectively. These results indicate a significant relationship between the presence of the D allele polymorphism in the ACE gene and ADR in Japanese subjects with type 2 diabetes and no overt nephropathy.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>11106834</pmid><doi>10.1016/S0168-8227(00)00194-7</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-8227 |
| ispartof | Diabetes research and clinical practice, 2000-12, Vol.50 (3), p.195-202 |
| issn | 0168-8227 1872-8227 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72458701 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Albuminuria Angiotensin-converting enzyme Associated diseases and complications Biological and medical sciences Blood Pressure Diabetes mellitus Diabetes Mellitus, Type 2 - enzymology Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Diabetic Retinopathy - enzymology Diabetic Retinopathy - genetics Diabetic Retinopathy - physiopathology Disease Progression DNA Transposable Elements Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Gene polymorphism Genotype Humans Male Medical sciences Middle Aged Nephropathy Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - metabolism Polymerase Chain Reaction Polymorphism, Genetic Proliferative retinopathy Reference Values Sequence Deletion |
| title | Detection of the association between a deletion polymorphism in the gene encoding angiotensin I-converting enzyme and advanced diabetic retinopathy |
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