Lipopolysaccharide-Binding Protein Accelerates and Augments Escherichia coli Phagocytosis by Alveolar Macrophages

Background. The first step in bacterial clearance by leukocytes is attachment and phagocytosis. Although lipopolysaccharide-binding protein (LBP) is best known for potentiating LPS-induced cytokine production through a CD14-dependent pathway, recent studies suggest that LBP plays a critical role in...

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Veröffentlicht in:	The Journal of surgical research 2000-12, Vol.94 (2), p.159-166
Hauptverfasser:	Klein, Richard D, Su, Grace L, Schmidt, Carl, Aminlari, Alireza, Steinstraesser, Lars, Alarcon, William H, Zhang, Hong Yu, Wang, Stewart C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Proteins Animals Bacterial Adhesion - drug effects Bacterial Adhesion - physiology Biological and medical sciences Carrier Proteins - pharmacology CD14 Cell structures and functions Cells, Cultured Escherichia coli Fluorescein-5-isothiocyanate Fundamental and applied biological sciences. Psychology Kinetics Lipopolysaccharide Receptors - physiology lipopolysaccharide-binding protein Lipopolysaccharides - pharmacology Macrophages, Alveolar - drug effects Macrophages, Alveolar - microbiology Macrophages, Alveolar - physiology Male Membrane Glycoproteins Miscellaneous Molecular and cellular biology phagocytosis Phagocytosis - drug effects Phagocytosis - physiology Phosphatidylinositol Diacylglycerol-Lyase Phosphoinositide Phospholipase C Rats Rats, Sprague-Dawley Recombinant Proteins - pharmacology Tumor Necrosis Factor-alpha - secretion Type C Phospholipases - metabolism
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