Mitogen Response of B Cells, but not T Cells, is Impaired in Adult Vitamin A-Deficient Rats
The effect of vitamin A deficiency on the mitogen response of splenic B and T lymphocytes was determined in adult vitamin A-deficient rats. Female weanling Brown Norway/Billingham-Rijswijk (BN/BiRij) and Sprague-Dawley rats were fed a semipurified, essentially vitamin A-free diet, which resulted in...
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| Veröffentlicht in: | The Journal of nutrition 1991-12, Vol.121 (12), p.1960-1968 |
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| container_end_page | 1968 |
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| container_issue | 12 |
| container_start_page | 1960 |
| container_title | The Journal of nutrition |
| container_volume | 121 |
| creator | van Bennekum, Ariëtte M. Kong, Letitia R. Wong Yen Gijbels, Marion J.J. Tielen, Frans J. Roholl, Paul J.M. Brouwer, Adriaan Hendriks, Henk F.J. |
| description | The effect of vitamin A deficiency on the mitogen response of splenic B and T lymphocytes was determined in adult vitamin A-deficient rats. Female weanling Brown Norway/Billingham-Rijswijk (BN/BiRij) and Sprague-Dawley rats were fed a semipurified, essentially vitamin A-free diet, which resulted in clinical symptoms of vitamin A deficiency and severely decreased plasma retinol contents at the age of about 17 and 41 wk for BN/BiRij and Sprague-Dawley rats, respectively. A lower B cell proliferative response after stimulation with lipopolysaccharide in combination with dextran sulfate was observed in vitamin A-deficient rats of both strains, but the T cell proliferative response after concanavalin A stimulation was unchanged. The lower B cell mitogen response was not associated with changes in the cellular composition of the spleen (as analyzed with monoclonal antibodies specific for the various subsets of T and B cells and of macrophages). We suggest that the age at which clinical symptoms of vitamin A deficiency are induced may be an important determinant for the immunological variables affected. |
| doi_str_mv | 10.1093/jn/121.12.1960 |
| format | Article |
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Wong Yen ; Gijbels, Marion J.J. ; Tielen, Frans J. ; Roholl, Paul J.M. ; Brouwer, Adriaan ; Hendriks, Henk F.J.</creator><creatorcontrib>van Bennekum, Ariëtte M. ; Kong, Letitia R. Wong Yen ; Gijbels, Marion J.J. ; Tielen, Frans J. ; Roholl, Paul J.M. ; Brouwer, Adriaan ; Hendriks, Henk F.J.</creatorcontrib><description>The effect of vitamin A deficiency on the mitogen response of splenic B and T lymphocytes was determined in adult vitamin A-deficient rats. Female weanling Brown Norway/Billingham-Rijswijk (BN/BiRij) and Sprague-Dawley rats were fed a semipurified, essentially vitamin A-free diet, which resulted in clinical symptoms of vitamin A deficiency and severely decreased plasma retinol contents at the age of about 17 and 41 wk for BN/BiRij and Sprague-Dawley rats, respectively. A lower B cell proliferative response after stimulation with lipopolysaccharide in combination with dextran sulfate was observed in vitamin A-deficient rats of both strains, but the T cell proliferative response after concanavalin A stimulation was unchanged. The lower B cell mitogen response was not associated with changes in the cellular composition of the spleen (as analyzed with monoclonal antibodies specific for the various subsets of T and B cells and of macrophages). We suggest that the age at which clinical symptoms of vitamin A deficiency are induced may be an important determinant for the immunological variables affected.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/121.12.1960</identifier><identifier>PMID: 1941260</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Animals ; Antibody Formation ; B-Lymphocytes - immunology ; BAZO ; Biological and medical sciences ; CARENCE EN VITAMINE ; Cell Division ; DEFICIENCIA DE VITAMINAS ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Immunobiology ; IMMUNOLOGIE ; immunology ; INMUNOLOGIA ; LINFOCITOS ; Liver - metabolism ; LYMPHOCYTE ; Mitogens - immunology ; Modulation of the immune response (stimulation, suppression) ; RAT ; RATA ; RATE ; Rats ; Rats, Inbred Strains ; RETINOL ; Species Specificity ; Spleen - immunology ; Spleen - pathology ; spleen lymphocytes ; T-Lymphocytes - immunology ; vitamin A ; Vitamin A Deficiency - immunology</subject><ispartof>The Journal of nutrition, 1991-12, Vol.121 (12), p.1960-1968</ispartof><rights>1991 American Society for Nutrition.</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-548c5ad173572aba2ec23e1365754976a039540dc605ef7e583c4468aec8b8053</citedby><cites>FETCH-LOGICAL-c427t-548c5ad173572aba2ec23e1365754976a039540dc605ef7e583c4468aec8b8053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5060390$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1941260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Bennekum, Ariëtte M.</creatorcontrib><creatorcontrib>Kong, Letitia R. Wong Yen</creatorcontrib><creatorcontrib>Gijbels, Marion J.J.</creatorcontrib><creatorcontrib>Tielen, Frans J.</creatorcontrib><creatorcontrib>Roholl, Paul J.M.</creatorcontrib><creatorcontrib>Brouwer, Adriaan</creatorcontrib><creatorcontrib>Hendriks, Henk F.J.</creatorcontrib><title>Mitogen Response of B Cells, but not T Cells, is Impaired in Adult Vitamin A-Deficient Rats</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>The effect of vitamin A deficiency on the mitogen response of splenic B and T lymphocytes was determined in adult vitamin A-deficient rats. Female weanling Brown Norway/Billingham-Rijswijk (BN/BiRij) and Sprague-Dawley rats were fed a semipurified, essentially vitamin A-free diet, which resulted in clinical symptoms of vitamin A deficiency and severely decreased plasma retinol contents at the age of about 17 and 41 wk for BN/BiRij and Sprague-Dawley rats, respectively. A lower B cell proliferative response after stimulation with lipopolysaccharide in combination with dextran sulfate was observed in vitamin A-deficient rats of both strains, but the T cell proliferative response after concanavalin A stimulation was unchanged. The lower B cell mitogen response was not associated with changes in the cellular composition of the spleen (as analyzed with monoclonal antibodies specific for the various subsets of T and B cells and of macrophages). We suggest that the age at which clinical symptoms of vitamin A deficiency are induced may be an important determinant for the immunological variables affected.</description><subject>Animals</subject><subject>Antibody Formation</subject><subject>B-Lymphocytes - immunology</subject><subject>BAZO</subject><subject>Biological and medical sciences</subject><subject>CARENCE EN VITAMINE</subject><subject>Cell Division</subject><subject>DEFICIENCIA DE VITAMINAS</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Immunobiology</subject><subject>IMMUNOLOGIE</subject><subject>immunology</subject><subject>INMUNOLOGIA</subject><subject>LINFOCITOS</subject><subject>Liver - metabolism</subject><subject>LYMPHOCYTE</subject><subject>Mitogens - immunology</subject><subject>Modulation of the immune response (stimulation, suppression)</subject><subject>RAT</subject><subject>RATA</subject><subject>RATE</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>RETINOL</subject><subject>Species Specificity</subject><subject>Spleen - immunology</subject><subject>Spleen - pathology</subject><subject>spleen lymphocytes</subject><subject>T-Lymphocytes - immunology</subject><subject>vitamin A</subject><subject>Vitamin A Deficiency - immunology</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE2LFDEQhoMo67h69SAIOYgnezaVTtLp4zp-LawI664XDyGTrl4ydKfHJC34703To548hCL1PlUUDyHPgW2BtfXFIVwAhy3wLbSKPSAbkAIqBYw9JBvGOK9qUOoxeZLSgTEGotVn5AxaAVyxDfn-2efpHgO9wXScQkI69fQt3eEwpDd0P2capkxv_zR8olfj0fqIHfWBXnbzkOk3n-24_Kp32HvnMWR6Y3N6Sh71dkj47FTPyd2H97e7T9X1l49Xu8vrygne5EoK7aTtoKllw-3ecnS8RqiVbKRoG2VZ3UrBOqeYxL5BqWsnhNIWnd5rJutz8nrde4zTjxlTNqNPrhxsA05zMg0XUmm-gNsVdHFKKWJvjtGPNv4ywMxi0xyCKTbLM4vNMvDytHnej9j9w1d9JX91ym1yduijDc6nv5hkhWkX7MWK9XYy9j4W5O5rC43mGkqo1xCLop8eo0mLQoddseyy6Sb_v_N-AzhylJ0</recordid><startdate>19911201</startdate><enddate>19911201</enddate><creator>van Bennekum, Ariëtte M.</creator><creator>Kong, Letitia R. 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Wong Yen</au><au>Gijbels, Marion J.J.</au><au>Tielen, Frans J.</au><au>Roholl, Paul J.M.</au><au>Brouwer, Adriaan</au><au>Hendriks, Henk F.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mitogen Response of B Cells, but not T Cells, is Impaired in Adult Vitamin A-Deficient Rats</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1991-12-01</date><risdate>1991</risdate><volume>121</volume><issue>12</issue><spage>1960</spage><epage>1968</epage><pages>1960-1968</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>The effect of vitamin A deficiency on the mitogen response of splenic B and T lymphocytes was determined in adult vitamin A-deficient rats. Female weanling Brown Norway/Billingham-Rijswijk (BN/BiRij) and Sprague-Dawley rats were fed a semipurified, essentially vitamin A-free diet, which resulted in clinical symptoms of vitamin A deficiency and severely decreased plasma retinol contents at the age of about 17 and 41 wk for BN/BiRij and Sprague-Dawley rats, respectively. A lower B cell proliferative response after stimulation with lipopolysaccharide in combination with dextran sulfate was observed in vitamin A-deficient rats of both strains, but the T cell proliferative response after concanavalin A stimulation was unchanged. The lower B cell mitogen response was not associated with changes in the cellular composition of the spleen (as analyzed with monoclonal antibodies specific for the various subsets of T and B cells and of macrophages). 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| subjects | Animals Antibody Formation B-Lymphocytes - immunology BAZO Biological and medical sciences CARENCE EN VITAMINE Cell Division DEFICIENCIA DE VITAMINAS Female Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology IMMUNOLOGIE immunology INMUNOLOGIA LINFOCITOS Liver - metabolism LYMPHOCYTE Mitogens - immunology Modulation of the immune response (stimulation, suppression) RAT RATA RATE Rats Rats, Inbred Strains RETINOL Species Specificity Spleen - immunology Spleen - pathology spleen lymphocytes T-Lymphocytes - immunology vitamin A Vitamin A Deficiency - immunology |
| title | Mitogen Response of B Cells, but not T Cells, is Impaired in Adult Vitamin A-Deficient Rats |
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