Growth Stimulation of Human Keratinocytes by Tissue Inhibitor of Metalloproteinases

Human recombinant tissue inhibitor of metalloproteinases (rTIMP) at 0.2-4.6 μM was found to stimulate the growth of normal human keratinocytes, in primary cultures on a plastic support, and to markedly increase their growth on a tridimensional culture system, the skin equivalent, as shown by histolo...

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Veröffentlicht in:	Journal of investigative dermatology 1991-10, Vol.97 (4), p.679-685
Hauptverfasser:	Bertaux, Brigitte, Hornebeck, William, Eisen, Arthur Z, Dubertret, Louis
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biological and medical sciences Cell Division - drug effects Cell physiology Cells, Cultured Extracellular Matrix Proteins - biosynthesis Fibroblasts - drug effects Fundamental and applied biological sciences. Psychology Glycoproteins - metabolism Glycoproteins - pharmacology Humans Keratinocytes - drug effects Keratinocytes - metabolism Metalloendopeptidases - antagonists & inhibitors Molecular and cellular biology Recombinant Proteins - metabolism Recombinant Proteins - pharmacology Responses to growth factors, tumor promotors, other factors Tissue Inhibitor of Metalloproteinases
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