Persistence of HIV-1 silent infection in seronegative subjects at high risk

Twenty regular sexual partners of HIV‐1 infected subjects, without detectable human irnmunodeficiency virus (HIV‐1) antibody and positive for HIV‐1 genome by in situ hybridization (ISH), were selected and studied longitudinally for 6–36 months to estimate the duration of silent infection. During the...

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Veröffentlicht in:	Journal of medical virology 1991-09, Vol.35 (1), p.14-18
Hauptverfasser:	Pezzella, Mario, Rosci, Maria A., Miceli, Michela, Vonesch, Nicoletta, Sturchio, Elena, Mirolo, Marina, Mannella, Emilio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS/HIV atypical WB patterns Biological and medical sciences Blotting, Western Carrier State - immunology Female Follow-Up Studies HIV Infections - immunology HIV Seropositivity Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology in situ hybridization Longitudinal Studies Male Medical sciences Middle Aged Nucleic Acid Hybridization Risk Factors Sexual Partners silent infection
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Beschreibung
Zusammenfassung:	Twenty regular sexual partners of HIV‐1 infected subjects, without detectable human irnmunodeficiency virus (HIV‐1) antibody and positive for HIV‐1 genome by in situ hybridization (ISH), were selected and studied longitudinally for 6–36 months to estimate the duration of silent infection. During the follow‐up period, 10 showed atypical Western Blot (WB) patterns. Two seronegative partners seroconverted. Rapid progress t o AIDS was observed in 7 seropositive subjects.
ISSN:	0146-6615 1096-9071
DOI:	10.1002/jmv.1890350104