Articular diffusion of Meloxicam after a single oral dose : Relationship to cyclo-oxygenase inhibition in synovial cells

To investigate the distribution of meloxicam in the human knee joint and to compare it with the inhibition of cyclo-oxygenase (COX) activity in synovial cells. Prospective pharmacokinetic study and in vitro laboratory investigation. 42 male and female patients aged 26 to 85 years hospitalised for rh...

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Veröffentlicht in:	Clinical pharmacokinetics 2000-11, Vol.39 (5), p.369-382
Hauptverfasser:	LAPICQUE, Francoise, VERGNE, Pascale, GAUCHER, Alain, BERTIN, Philippe, NETTER, Patrick, JOUZEAU, Jean-Yves, LOEUILLE, Damien, GILLET, Pierre, VIGNON, Eric, THOMAS, Philippe, VELICITAT, Patrick, TÜRCK, Dietrich, GUILLAUME, Cécile
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Aged Aged, 80 and over Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Area Under Curve Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cyclooxygenase Inhibitors - pharmacokinetics Diffusion Female Humans Knee Joint - metabolism Male Medical sciences Middle Aged Pharmacology. Drug treatments Prospective Studies Protein Binding Synovial Fluid - metabolism Thiazines - administration & dosage Thiazines - pharmacokinetics Thiazines - pharmacology Thiazoles - administration & dosage Thiazoles - pharmacokinetics Thiazoles - pharmacology
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