Candida albicans Stimulates Endothelial Cell Eicosanoid Production
The response of human umbilical vein endothelial cells to invasion by Candida species was examined in vitro. Live Candida albicans caused significant endothelial release of eicosanoids, mainly prostaglandins. Since prostaglandin I2 (PGI2) is an important prostaglandin produced by endothelial cells,...
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| Veröffentlicht in: | The Journal of infectious diseases 1991-11, Vol.164 (5), p.928-935 |
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| container_issue | 5 |
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| container_title | The Journal of infectious diseases |
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| creator | Filler, Scott G. Ibe, Basil O. Luckett, Peter M. Raj, J. Usha Edwards, John E. |
| description | The response of human umbilical vein endothelial cells to invasion by Candida species was examined in vitro. Live Candida albicans caused significant endothelial release of eicosanoids, mainly prostaglandins. Since prostaglandin I2 (PGI2) is an important prostaglandin produced by endothelial cells, factors influencing its release were studied. The ability of different strains and species of Candida to induce endothelial PGI2 release was closely related to their capacity to injure the endothelium (r = .99). C. albicans was the only species tested that either stimulated PGI2 release or damaged the endothelial cells; only this organism possessed detectable phospholipase activity. Candida glabrata and Candida tropicalis had no phospholipase activity and neither increased PGI2 release nor caused significant endothelial damage. Close proximity with germinated C. albicans was required for endothelial injury and PGI2 release. The ability of C. albicans to stimulate endothelial cells may have important implications in regulating neutrophil activities against organisms that interact with endothelial cells. |
| doi_str_mv | 10.1093/infdis/164.5.928 |
| format | Article |
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Usha ; Edwards, John E.</creator><creatorcontrib>Filler, Scott G. ; Ibe, Basil O. ; Luckett, Peter M. ; Raj, J. Usha ; Edwards, John E.</creatorcontrib><description>The response of human umbilical vein endothelial cells to invasion by Candida species was examined in vitro. Live Candida albicans caused significant endothelial release of eicosanoids, mainly prostaglandins. Since prostaglandin I2 (PGI2) is an important prostaglandin produced by endothelial cells, factors influencing its release were studied. The ability of different strains and species of Candida to induce endothelial PGI2 release was closely related to their capacity to injure the endothelium (r = .99). C. albicans was the only species tested that either stimulated PGI2 release or damaged the endothelial cells; only this organism possessed detectable phospholipase activity. Candida glabrata and Candida tropicalis had no phospholipase activity and neither increased PGI2 release nor caused significant endothelial damage. Close proximity with germinated C. albicans was required for endothelial injury and PGI2 release. The ability of C. albicans to stimulate endothelial cells may have important implications in regulating neutrophil activities against organisms that interact with endothelial cells.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/164.5.928</identifier><identifier>PMID: 1940471</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Arachidonic Acid - biosynthesis ; Candida albicans ; Candida albicans - enzymology ; Candida albicans - immunology ; Cells, Cultured ; Cultured cells ; Eicosanoids ; Eicosanoids - biosynthesis ; Endothelial cells ; Endothelium ; Endothelium, Vascular - cytology ; Endothelium, Vascular - immunology ; Endothelium, Vascular - pathology ; Epoprostenol - biosynthesis ; Essential fatty acids ; Humans ; Hydroxyeicosatetraenoic Acids - biosynthesis ; Leukotrienes ; Major Articles ; Neutrophils ; Phospholipases - analysis ; Prostaglandins ; Prostaglandins - biosynthesis ; Species Specificity ; Sprains and strains</subject><ispartof>The Journal of infectious diseases, 1991-11, Vol.164 (5), p.928-935</ispartof><rights>Copyright 1991 The University of Chicago</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-84882151833ab2960a656047907bfc071a3ac8096b338e16331df1d5cb189e7c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30112005$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30112005$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1940471$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Filler, Scott G.</creatorcontrib><creatorcontrib>Ibe, Basil O.</creatorcontrib><creatorcontrib>Luckett, Peter M.</creatorcontrib><creatorcontrib>Raj, J. Usha</creatorcontrib><creatorcontrib>Edwards, John E.</creatorcontrib><title>Candida albicans Stimulates Endothelial Cell Eicosanoid Production</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>The response of human umbilical vein endothelial cells to invasion by Candida species was examined in vitro. Live Candida albicans caused significant endothelial release of eicosanoids, mainly prostaglandins. Since prostaglandin I2 (PGI2) is an important prostaglandin produced by endothelial cells, factors influencing its release were studied. The ability of different strains and species of Candida to induce endothelial PGI2 release was closely related to their capacity to injure the endothelium (r = .99). C. albicans was the only species tested that either stimulated PGI2 release or damaged the endothelial cells; only this organism possessed detectable phospholipase activity. Candida glabrata and Candida tropicalis had no phospholipase activity and neither increased PGI2 release nor caused significant endothelial damage. Close proximity with germinated C. albicans was required for endothelial injury and PGI2 release. The ability of C. albicans to stimulate endothelial cells may have important implications in regulating neutrophil activities against organisms that interact with endothelial cells.</description><subject>Arachidonic Acid - biosynthesis</subject><subject>Candida albicans</subject><subject>Candida albicans - enzymology</subject><subject>Candida albicans - immunology</subject><subject>Cells, Cultured</subject><subject>Cultured cells</subject><subject>Eicosanoids</subject><subject>Eicosanoids - biosynthesis</subject><subject>Endothelial cells</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - cytology</subject><subject>Endothelium, Vascular - immunology</subject><subject>Endothelium, Vascular - pathology</subject><subject>Epoprostenol - biosynthesis</subject><subject>Essential fatty acids</subject><subject>Humans</subject><subject>Hydroxyeicosatetraenoic Acids - biosynthesis</subject><subject>Leukotrienes</subject><subject>Major Articles</subject><subject>Neutrophils</subject><subject>Phospholipases - analysis</subject><subject>Prostaglandins</subject><subject>Prostaglandins - biosynthesis</subject><subject>Species Specificity</subject><subject>Sprains and strains</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1v1TAQxC1EVV4Ldy5IOXHL6643_jrC04OCiloJEBUXy7Ed4ZIXlziRyn_foFTtkdMefjOj2WHsNcIWwdBZGrqQyhnKZiu2hutnbIOCVC0l0nO2AeC8Rm3MC3ZSyg0ANCTVMTtG00CjcMPe79wQUnCV69vk3VCqr1M6zL2bYqn2Q8jTr9gn11e72PfVPvlc3JBTqK7GHGY_pTy8ZEed60t89XBP2fcP-2-78_ri8uOn3buL2pMWU60brTkK1ESu5UaCk0IuJQyotvOg0JHzGoxsiXRESYShwyB8uzwQladT9nbNvR3znzmWyR5S8UstN8Q8F6t4I7gy6r9ClFxKCbQIYRX6MZcyxs7ejungxr8Wwf7b1677Lo7GCrvsu1jePGTP7SGGJ8M66BO_KVMeHzEBIgcQC69XnsoU7x65G39bqUgJe379034RBvHH52uLdA_bEY6a</recordid><startdate>19911101</startdate><enddate>19911101</enddate><creator>Filler, Scott G.</creator><creator>Ibe, Basil O.</creator><creator>Luckett, Peter M.</creator><creator>Raj, J. Usha</creator><creator>Edwards, John E.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>19911101</creationdate><title>Candida albicans Stimulates Endothelial Cell Eicosanoid Production</title><author>Filler, Scott G. ; Ibe, Basil O. ; Luckett, Peter M. ; Raj, J. Usha ; Edwards, John E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-84882151833ab2960a656047907bfc071a3ac8096b338e16331df1d5cb189e7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Arachidonic Acid - biosynthesis</topic><topic>Candida albicans</topic><topic>Candida albicans - enzymology</topic><topic>Candida albicans - immunology</topic><topic>Cells, Cultured</topic><topic>Cultured cells</topic><topic>Eicosanoids</topic><topic>Eicosanoids - biosynthesis</topic><topic>Endothelial cells</topic><topic>Endothelium</topic><topic>Endothelium, Vascular - cytology</topic><topic>Endothelium, Vascular - immunology</topic><topic>Endothelium, Vascular - pathology</topic><topic>Epoprostenol - biosynthesis</topic><topic>Essential fatty acids</topic><topic>Humans</topic><topic>Hydroxyeicosatetraenoic Acids - biosynthesis</topic><topic>Leukotrienes</topic><topic>Major Articles</topic><topic>Neutrophils</topic><topic>Phospholipases - analysis</topic><topic>Prostaglandins</topic><topic>Prostaglandins - biosynthesis</topic><topic>Species Specificity</topic><topic>Sprains and strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Filler, Scott G.</creatorcontrib><creatorcontrib>Ibe, Basil O.</creatorcontrib><creatorcontrib>Luckett, Peter M.</creatorcontrib><creatorcontrib>Raj, J. Usha</creatorcontrib><creatorcontrib>Edwards, John E.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Filler, Scott G.</au><au>Ibe, Basil O.</au><au>Luckett, Peter M.</au><au>Raj, J. Usha</au><au>Edwards, John E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Candida albicans Stimulates Endothelial Cell Eicosanoid Production</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1991-11-01</date><risdate>1991</risdate><volume>164</volume><issue>5</issue><spage>928</spage><epage>935</epage><pages>928-935</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>The response of human umbilical vein endothelial cells to invasion by Candida species was examined in vitro. Live Candida albicans caused significant endothelial release of eicosanoids, mainly prostaglandins. Since prostaglandin I2 (PGI2) is an important prostaglandin produced by endothelial cells, factors influencing its release were studied. The ability of different strains and species of Candida to induce endothelial PGI2 release was closely related to their capacity to injure the endothelium (r = .99). C. albicans was the only species tested that either stimulated PGI2 release or damaged the endothelial cells; only this organism possessed detectable phospholipase activity. Candida glabrata and Candida tropicalis had no phospholipase activity and neither increased PGI2 release nor caused significant endothelial damage. Close proximity with germinated C. albicans was required for endothelial injury and PGI2 release. The ability of C. albicans to stimulate endothelial cells may have important implications in regulating neutrophil activities against organisms that interact with endothelial cells.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>1940471</pmid><doi>10.1093/infdis/164.5.928</doi><tpages>8</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1991-11, Vol.164 (5), p.928-935 |
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| language | eng |
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| source | MEDLINE; Jstor Complete Legacy |
| subjects | Arachidonic Acid - biosynthesis Candida albicans Candida albicans - enzymology Candida albicans - immunology Cells, Cultured Cultured cells Eicosanoids Eicosanoids - biosynthesis Endothelial cells Endothelium Endothelium, Vascular - cytology Endothelium, Vascular - immunology Endothelium, Vascular - pathology Epoprostenol - biosynthesis Essential fatty acids Humans Hydroxyeicosatetraenoic Acids - biosynthesis Leukotrienes Major Articles Neutrophils Phospholipases - analysis Prostaglandins Prostaglandins - biosynthesis Species Specificity Sprains and strains |
| title | Candida albicans Stimulates Endothelial Cell Eicosanoid Production |
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