The hydrophobic photoreagent 3-(trifluoromethyl)-3-m-([125I] iodophenyl) diazirine is a novel noncompetitive antagonist of the nicotinic acetylcholine receptor

We have shown previously that the lipophilic photoreagent 3-(trifluoromethyl)3-m-([125I]iodophenyl)-diazirine ([125I]TID) photolabels all four subunits of the Torpedo nicotinic acetylcholine receptor (AChR) and that greater than 70% of this photoincorporation is inhibited by cholinergic agonists and...

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Veröffentlicht in:	The Journal of biological chemistry 1991-11, Vol.266 (32), p.21595-21607
Hauptverfasser:	White, B H, Howard, S, Cohen, S G, Cohen, J B
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Labels Amphibian Venoms - metabolism Amphibian Venoms - pharmacology Animals Azirines - metabolism Azirines - pharmacology Carbachol - pharmacology Cell Membrane - metabolism Electric Organ - metabolism Iodine Radioisotopes Kinetics Macromolecular Substances Nicotinic Antagonists Phencyclidine - pharmacology Receptors, Nicotinic - drug effects Receptors, Nicotinic - metabolism Sodium - metabolism Torpedo
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