Influence of adjuvants on the antibody specificity to the Plasmodium falciparum major merozoite surface protein, gp195
The effect of adjuvants on the specificity of immune responses to the Plasmodium falciparum gp195 protein was investigated using adjuvant formulations based on synthetic muramyl dipeptide and monophosphoryl lipid A derivatives, in parallel with CFA and alum. Although these immunomodulators were as e...
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| Veröffentlicht in: | The Journal of immunology (1950) 1991-12, Vol.147 (11), p.3935-3941 |
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| container_end_page | 3941 |
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| container_issue | 11 |
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| container_title | The Journal of immunology (1950) |
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| creator | Hui, GS Chang, SP Gibson, H Hashimoto, A Hashiro, C Barr, PJ Kotani, S |
| description | The effect of adjuvants on the specificity of immune responses to the Plasmodium falciparum gp195 protein was investigated using adjuvant formulations based on synthetic muramyl dipeptide and monophosphoryl lipid A derivatives, in parallel with CFA and alum. Although these immunomodulators were as effective as CFA in inducing an antibody response to gp195, there were distinct differences in the recognition of B cell epitopes by these antibody populations. We have also demonstrated that MHC control of antibody specificity can be related to the adjuvant used for immunization. In general, the potency of adjuvants, their ability to induce antibodies of a particular specificity, or their ability to overcome MHC control of immune responsiveness varied independently. These findings suggest a critical role of adjuvants in the determination of the specificity of the immune response to protein Ag. Thus, the influence of adjuvants should be a major consideration in studies on immunologic recognition, as well as in the design of modern subunit vaccines. |
| doi_str_mv | 10.4049/jimmunol.147.11.3935 |
| format | Article |
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Although these immunomodulators were as effective as CFA in inducing an antibody response to gp195, there were distinct differences in the recognition of B cell epitopes by these antibody populations. We have also demonstrated that MHC control of antibody specificity can be related to the adjuvant used for immunization. In general, the potency of adjuvants, their ability to induce antibodies of a particular specificity, or their ability to overcome MHC control of immune responsiveness varied independently. These findings suggest a critical role of adjuvants in the determination of the specificity of the immune response to protein Ag. 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Psychology ; Fundamental immunology ; Immunobiology ; Membrane Glycoproteins - immunology ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Peptides - immunology ; Plasmodium falciparum - immunology ; Protozoan Proteins - immunology ; Recombinant Proteins - immunology</subject><ispartof>The Journal of immunology (1950), 1991-12, Vol.147 (11), p.3935-3941</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-6431ffda3d7149877d19484ef9264076798562310a7177037165505ad2896133</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5103780$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1940375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hui, GS</creatorcontrib><creatorcontrib>Chang, SP</creatorcontrib><creatorcontrib>Gibson, H</creatorcontrib><creatorcontrib>Hashimoto, A</creatorcontrib><creatorcontrib>Hashiro, C</creatorcontrib><creatorcontrib>Barr, PJ</creatorcontrib><creatorcontrib>Kotani, S</creatorcontrib><title>Influence of adjuvants on the antibody specificity to the Plasmodium falciparum major merozoite surface protein, gp195</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>The effect of adjuvants on the specificity of immune responses to the Plasmodium falciparum gp195 protein was investigated using adjuvant formulations based on synthetic muramyl dipeptide and monophosphoryl lipid A derivatives, in parallel with CFA and alum. Although these immunomodulators were as effective as CFA in inducing an antibody response to gp195, there were distinct differences in the recognition of B cell epitopes by these antibody populations. We have also demonstrated that MHC control of antibody specificity can be related to the adjuvant used for immunization. In general, the potency of adjuvants, their ability to induce antibodies of a particular specificity, or their ability to overcome MHC control of immune responsiveness varied independently. These findings suggest a critical role of adjuvants in the determination of the specificity of the immune response to protein Ag. Thus, the influence of adjuvants should be a major consideration in studies on immunologic recognition, as well as in the design of modern subunit vaccines.</description><subject>Adjuvants, Immunologic</subject><subject>Amino Acid Sequence</subject><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Animals</subject><subject>Antibodies, Protozoan - immunology</subject><subject>Antibody production</subject><subject>Antibody Specificity</subject><subject>Antigens, Protozoan - immunology</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Immunobiology</subject><subject>Membrane Glycoproteins - immunology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Molecular Sequence Data</subject><subject>Peptides - immunology</subject><subject>Plasmodium falciparum - immunology</subject><subject>Protozoan Proteins - immunology</subject><subject>Recombinant Proteins - immunology</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUV1vFCEUJUZT1-o_0IQHY3xwVu7AwPDYNH40adI-9J1QBrpsYBhhppv110u7q-2jT9zkno97OAi9B7JmhMmvWx_jMqawBibWAGsqafcCraDrSMM54S_RipC2bUBw8Rq9KWVLCOGkZSfoBCQjVHQrdH8xurDY0VicHNbDdrnX41xwGvG8sbjO_jYNe1wma7zzxs97PKfH3XXQJabBLxE7HYyfdK5j1NuUcbQ5_U5-trgs2emqPuU0Wz9-wXcTyO4telU5xb47vqfo5vu3m_OfzeXVj4vzs8vGMAZzwxkF5wZNBwFM9kIM9fCeWSdbzkjNJfuOtxSIFiBETQS8pu_00PaSA6Wn6NNBtrr_WmyZVfTF2BD0aNNSlGhZR-h_AKH-p2x7UoHsADQ5lZKtU1P2Uee9AqIealF_a1G1FgWgHmqptA9H_eU22uGJdOih7j8e97oYHVzWo_HlH6yDinp0_3yAbfzdZuezVSXqEKooqN1u99zxD5nBpNg</recordid><startdate>19911201</startdate><enddate>19911201</enddate><creator>Hui, GS</creator><creator>Chang, SP</creator><creator>Gibson, H</creator><creator>Hashimoto, A</creator><creator>Hashiro, C</creator><creator>Barr, PJ</creator><creator>Kotani, S</creator><general>Am Assoc Immnol</general><general>American Association of Immunologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>19911201</creationdate><title>Influence of adjuvants on the antibody specificity to the Plasmodium falciparum major merozoite surface protein, gp195</title><author>Hui, GS ; Chang, SP ; Gibson, H ; Hashimoto, A ; Hashiro, C ; Barr, PJ ; Kotani, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-6431ffda3d7149877d19484ef9264076798562310a7177037165505ad2896133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adjuvants, Immunologic</topic><topic>Amino Acid Sequence</topic><topic>Analysis of the immune response. 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Psychology</topic><topic>Fundamental immunology</topic><topic>Immunobiology</topic><topic>Membrane Glycoproteins - immunology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Molecular Sequence Data</topic><topic>Peptides - immunology</topic><topic>Plasmodium falciparum - immunology</topic><topic>Protozoan Proteins - immunology</topic><topic>Recombinant Proteins - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hui, GS</creatorcontrib><creatorcontrib>Chang, SP</creatorcontrib><creatorcontrib>Gibson, H</creatorcontrib><creatorcontrib>Hashimoto, A</creatorcontrib><creatorcontrib>Hashiro, C</creatorcontrib><creatorcontrib>Barr, PJ</creatorcontrib><creatorcontrib>Kotani, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hui, GS</au><au>Chang, SP</au><au>Gibson, H</au><au>Hashimoto, A</au><au>Hashiro, C</au><au>Barr, PJ</au><au>Kotani, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of adjuvants on the antibody specificity to the Plasmodium falciparum major merozoite surface protein, gp195</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>1991-12-01</date><risdate>1991</risdate><volume>147</volume><issue>11</issue><spage>3935</spage><epage>3941</epage><pages>3935-3941</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><coden>JOIMA3</coden><abstract>The effect of adjuvants on the specificity of immune responses to the Plasmodium falciparum gp195 protein was investigated using adjuvant formulations based on synthetic muramyl dipeptide and monophosphoryl lipid A derivatives, in parallel with CFA and alum. Although these immunomodulators were as effective as CFA in inducing an antibody response to gp195, there were distinct differences in the recognition of B cell epitopes by these antibody populations. We have also demonstrated that MHC control of antibody specificity can be related to the adjuvant used for immunization. In general, the potency of adjuvants, their ability to induce antibodies of a particular specificity, or their ability to overcome MHC control of immune responsiveness varied independently. These findings suggest a critical role of adjuvants in the determination of the specificity of the immune response to protein Ag. Thus, the influence of adjuvants should be a major consideration in studies on immunologic recognition, as well as in the design of modern subunit vaccines.</abstract><cop>Bethesda, MD</cop><pub>Am Assoc Immnol</pub><pmid>1940375</pmid><doi>10.4049/jimmunol.147.11.3935</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adjuvants, Immunologic Amino Acid Sequence Analysis of the immune response. Humoral and cellular immunity Animals Antibodies, Protozoan - immunology Antibody production Antibody Specificity Antigens, Protozoan - immunology Biological and medical sciences Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology Membrane Glycoproteins - immunology Mice Mice, Inbred C57BL Molecular Sequence Data Peptides - immunology Plasmodium falciparum - immunology Protozoan Proteins - immunology Recombinant Proteins - immunology |
| title | Influence of adjuvants on the antibody specificity to the Plasmodium falciparum major merozoite surface protein, gp195 |
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