Effects of intracellular calcium elevation on action potential and L-type calcium current of normal and chronically infarcted rat ventricles

The present work investigated the effects of raising [Ca+2]i levels on action potential (AP) and L-type calcium current (ICa.L) of normal and chronically infarcted rat ventricles. Experiments were performed by conventional electrophysiology and whole-cell patch-clamp techniques. In the former, APs w...

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Veröffentlicht in:	Journal of electrocardiology 2000-10, Vol.33 (4), p.361-374
Hauptverfasser:	Lima, Zaira Fernandes, de Brito Santos, Paulo Eustáquio
Format:	Artikel
Sprache:	eng
Schlagworte:	action potential Action Potentials Animals Biological and medical sciences Calcium - metabolism Calcium - physiology Calcium Channels, L-Type - physiology Cardiomyopathy, Hypertrophic - physiopathology chloride currents Chlorides - physiology Data Interpretation, Statistical Electrocardiography. Vectocardiography Electrodiagnosis. Electric activity recording Electrophysiology Female Healed myocardial infarction Heart Ventricles - cytology Heart Ventricles - physiopathology In Vitro Techniques Investigative techniques, diagnostic techniques (general aspects) Kinetics L-type calcium current Male Medical sciences myocardial hypertrophy Myocardial Infarction - metabolism Myocardial Infarction - physiopathology Patch-Clamp Techniques Rats Rats, Wistar
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