Enhancing Effect of Pyrrolidone Derivatives on Transdermal Penetration of 5-Fluorouracil, Triamcinolone Acetonide, Indomethacin, and Flurbiprofen

The enhancing effects of pyrrolidone derivatives on the transdermal penetration of 5-fluorouracil, triamcinolone acetonide, indomethacin, and flurbiprofen were studied by using an in vitro technique and full-thickness rat skin. The enhancers included 1-methyl (1), 1-hexyl (2), and 1 -lauryl-2- pyrro...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1991-06, Vol.80 (6), p.533-538
Hauptverfasser:	Sasaki, Hitoshi, Kojima, Masaki, Mori, Yoshiyuki, Nakamura, Junzo, Shibasaki, Juichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Antineoplastic agents Biological and medical sciences Biological Availability Chemical Phenomena Chemistry, Physical Chromatography, High Pressure Liquid Fluorouracil - pharmacokinetics Flurbiprofen - pharmacokinetics General aspects Indomethacin - pharmacokinetics Male Medical sciences Myristates Pharmacology. Drug treatments Pyrrolidinones - pharmacology Rats Rats, Inbred Strains Skin Absorption - drug effects Solubility - drug effects Triamcinolone Acetonide - pharmacokinetics
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