Systemic absorption of insulin delivered topically to the rat eye

Insulin administration in eye drops containing 1% saponin caused a rapid and reproducible reduction in blood levels of D-glucose in anesthetized rats; insulin eye drops lacking saponin were ineffective. Systemic insulin absorption also was observed when Brij 78 or BL-9 was substituted for saponin in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Investigative ophthalmology & visual science 1991-11, Vol.32 (12), p.3021-3027
Hauptverfasser:	Pillion, DJ, Bartlett, JD, Meezan, E, Yang, M, Crain, RJ, Grizzle, WE
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Administration, Topical Animals Biological and medical sciences Blood Glucose - metabolism Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Disease Models, Animal Drug Carriers Eye Eye - metabolism Insulin - administration & dosage Insulin - pharmacokinetics Male Medical sciences Nasolacrimal Duct - diagnostic imaging Nasolacrimal Duct - metabolism Ophthalmic Solutions Pharmacology. Drug treatments Radiography Rats Rats, Inbred Strains Streptozocin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!