Decreased activities of ubiquinol:ferricytochrome c oxidoreductase (complex III) and ferrocytochrome c:oxygen oxidoreductase (complex IV) in liver mitochondria from rats with hydroxycobalamin[c-lactam]-induced methylmalonic aciduria

Rats treated with hydroxycobalamin[c-lactam] (HCCL), a cobalamin analogue that induces methylmalonic aciduria, have increased hepatic mitochondrial content and increased oxidative metabolism of pyruvate and palmitate per hepatocyte. The present studies were undertaken to characterize oxidative metab...

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Veröffentlicht in:	The Journal of biological chemistry 1991-11, Vol.266 (31), p.20998-21003
Hauptverfasser:	Krahenbuhl, S., Chang, M., Brass, E.P., Hoppel, C.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell structures and functions cytochrome-c oxidase Electron Transport - drug effects Electron Transport Complex III - metabolism Electron Transport Complex IV - metabolism Fundamental and applied biological sciences. Psychology hydroxycobalamin(c-lactam) Male Methylmalonic Acid - urine Mitochondria and cell respiration Mitochondria, Liver - metabolism Molecular and cellular biology Oxygen Consumption - drug effects Rats Rats, Inbred F344 Vitamin B 12 - analogs & derivatives Vitamin B 12 - antagonists & inhibitors Vitamin B 12 - pharmacology Vitamin B 12 Deficiency - metabolism
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