Misoprostol but not antacid prevents endotoxin-induced gastric mucosal injury: role of tumor necrosis factor-alpha

Many of the complications of septic shock are believed to be a consequence of elevated circulating levels of tumor necrosis factor (TNF), which is an important mediator of tissue injury. Prostaglandins (PGs) of the E series have recently been reported to inhibit TNF production in vitro. We investiga...

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Veröffentlicht in:	Digestive diseases and sciences 1991-11, Vol.36 (11), p.1562-1568
Hauptverfasser:	Mahatma, M, Agrawal, N, Dajani, E Z, Nelson, S, Nakamura, C, Sitton, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aluminum Hydroxide - pharmacology Animals Antacids - pharmacology Dose-Response Relationship, Drug Drug Combinations Gastric Mucosa - drug effects Magnesium Hydroxide - pharmacology Male Misoprostol - pharmacology Neutrophils - drug effects Rats Rats, Inbred Strains Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism
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