Role of superoxide dismutase in the oxidation of N-alkanes by yeasts
Yeast microorganisms from Candida genus are investigated for their superoxide dismutase (SOD) and catalase activity during cultivation on N-alkanes. The later caused a considerable increase of Cu/Zn SOD activity of yeast cells in comparison with glucose. A correlation between SOD and catalase activi...
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| Veröffentlicht in: | Free radical biology & medicine 1991, Vol.11 (3), p.263-268 |
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| creator | Kujumdzieva-Savova, Anna V. Savov, Valentin A. Georgieva, Elena I. |
| description | Yeast microorganisms from
Candida genus are investigated for their superoxide dismutase (SOD) and catalase activity during cultivation on
N-alkanes. The later caused a considerable increase of Cu/Zn SOD activity of yeast cells in comparison with glucose. A correlation between SOD and catalase activity existed. It is further observed that cells of
Candida lipolytica 68–72 which contain a high level of Cu/Zn SOD were more resistant to lethality of exogenous O
2
−. An over-production of Cu/Zn SOD during the assimilation of
N-alkanes by yeasts is also connected to their considerable resistance to increased concentrations of Cu
2+ and Zn
2+ ions in the nutrient medium. The results are consistent with the assumption that the enhanced resistance of yeast cells to O
2
− and high concentrations of Cu
2+ and Zn
2+-ions are due to the increased activity of Cu/Zn SOD and that SOD is involved in the protection of some cellular components.
Polyacrylamide gel electrophoresis of
Candida lipolutica cell-free extracts revealed the same chromatic bands of SOD activity under growth on glucose and
N-alkanes. The type of the carbon source used from yeast cells as a single source of carbon and energy had no influence on the SOD profile of the cell. |
| doi_str_mv | 10.1016/0891-5849(91)90122-J |
| format | Article |
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Candida genus are investigated for their superoxide dismutase (SOD) and catalase activity during cultivation on
N-alkanes. The later caused a considerable increase of Cu/Zn SOD activity of yeast cells in comparison with glucose. A correlation between SOD and catalase activity existed. It is further observed that cells of
Candida lipolytica 68–72 which contain a high level of Cu/Zn SOD were more resistant to lethality of exogenous O
2
−. An over-production of Cu/Zn SOD during the assimilation of
N-alkanes by yeasts is also connected to their considerable resistance to increased concentrations of Cu
2+ and Zn
2+ ions in the nutrient medium. The results are consistent with the assumption that the enhanced resistance of yeast cells to O
2
− and high concentrations of Cu
2+ and Zn
2+-ions are due to the increased activity of Cu/Zn SOD and that SOD is involved in the protection of some cellular components.
Polyacrylamide gel electrophoresis of
Candida lipolutica cell-free extracts revealed the same chromatic bands of SOD activity under growth on glucose and
N-alkanes. The type of the carbon source used from yeast cells as a single source of carbon and energy had no influence on the SOD profile of the cell.</description><identifier>ISSN: 0891-5849</identifier><identifier>EISSN: 1873-4596</identifier><identifier>DOI: 10.1016/0891-5849(91)90122-J</identifier><identifier>PMID: 1657738</identifier><identifier>CODEN: FRBMEH</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Alkanes - metabolism ; Alkanes - pharmacology ; Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Candida ; Candida - drug effects ; Candida - enzymology ; Candida - growth & development ; Candida lipolytica ; Catalase ; Catalase - biosynthesis ; Enzymes and enzyme inhibitors ; Free Radicals ; Fundamental and applied biological sciences. Psychology ; Glucose - pharmacology ; N-Alkanes ; Oxidation ; Oxidation-Reduction ; Superoxide Dismutase ; Superoxide Dismutase - antagonists & inhibitors ; Superoxide Dismutase - biosynthesis ; Superoxide Dismutase - physiology ; Superoxides - pharmacology ; Yeast</subject><ispartof>Free radical biology & medicine, 1991, Vol.11 (3), p.263-268</ispartof><rights>1991</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-7542961ce5ced978ee22e0efb29c15609866ff634bab2c42adf2f92102c00fba3</citedby><cites>FETCH-LOGICAL-c417t-7542961ce5ced978ee22e0efb29c15609866ff634bab2c42adf2f92102c00fba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0891-5849(91)90122-J$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5294812$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1657738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kujumdzieva-Savova, Anna V.</creatorcontrib><creatorcontrib>Savov, Valentin A.</creatorcontrib><creatorcontrib>Georgieva, Elena I.</creatorcontrib><title>Role of superoxide dismutase in the oxidation of N-alkanes by yeasts</title><title>Free radical biology & medicine</title><addtitle>Free Radic Biol Med</addtitle><description>Yeast microorganisms from
Candida genus are investigated for their superoxide dismutase (SOD) and catalase activity during cultivation on
N-alkanes. The later caused a considerable increase of Cu/Zn SOD activity of yeast cells in comparison with glucose. A correlation between SOD and catalase activity existed. It is further observed that cells of
Candida lipolytica 68–72 which contain a high level of Cu/Zn SOD were more resistant to lethality of exogenous O
2
−. An over-production of Cu/Zn SOD during the assimilation of
N-alkanes by yeasts is also connected to their considerable resistance to increased concentrations of Cu
2+ and Zn
2+ ions in the nutrient medium. The results are consistent with the assumption that the enhanced resistance of yeast cells to O
2
− and high concentrations of Cu
2+ and Zn
2+-ions are due to the increased activity of Cu/Zn SOD and that SOD is involved in the protection of some cellular components.
Polyacrylamide gel electrophoresis of
Candida lipolutica cell-free extracts revealed the same chromatic bands of SOD activity under growth on glucose and
N-alkanes. The type of the carbon source used from yeast cells as a single source of carbon and energy had no influence on the SOD profile of the cell.</description><subject>Alkanes - metabolism</subject><subject>Alkanes - pharmacology</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Candida</subject><subject>Candida - drug effects</subject><subject>Candida - enzymology</subject><subject>Candida - growth & development</subject><subject>Candida lipolytica</subject><subject>Catalase</subject><subject>Catalase - biosynthesis</subject><subject>Enzymes and enzyme inhibitors</subject><subject>Free Radicals</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose - pharmacology</subject><subject>N-Alkanes</subject><subject>Oxidation</subject><subject>Oxidation-Reduction</subject><subject>Superoxide Dismutase</subject><subject>Superoxide Dismutase - antagonists & inhibitors</subject><subject>Superoxide Dismutase - biosynthesis</subject><subject>Superoxide Dismutase - physiology</subject><subject>Superoxides - pharmacology</subject><subject>Yeast</subject><issn>0891-5849</issn><issn>1873-4596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhq2Kqiyl_6BIOaCKHlI8ju3EFyRUKKWqioTgbDnOWDVkk60nqdh_j8Ouyg1OI837zIcexk6BXwAH_ZY3BkrVSPPGwLnhIER5c8BW0NRVKZXRz9jqCXnOXhD94JxLVTVH7Ai0quuqWbEPX8ceizEUNG8wjb9ih0UXaT1PjrCIQzHd5zi33RTHYQHvStf_dANS0W6LLTqa6CU7DK4nPNnXY_b96uO3y-vy9sunz5fvb0svoZ7KWklhNHhUHjtTN4hCIMfQCuNBaW4arUPQlWxdK7wUrgsiGAFceM5D66pjdrbbu0njw4w02XUkj32f3xlnsrWQUoGG_4KghZI1FxmUO9CnkShhsJsU1y5tLXC7WLaLQrsotLn-sWxv8tir_f65XWP3d2inNeev97kj7_qQ3OAjPWFKGNnAcv3dDsMs7TFisuQjDtlOTOgn243x33_8BqF8l_U</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>Kujumdzieva-Savova, Anna V.</creator><creator>Savov, Valentin A.</creator><creator>Georgieva, Elena I.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>1991</creationdate><title>Role of superoxide dismutase in the oxidation of N-alkanes by yeasts</title><author>Kujumdzieva-Savova, Anna V. ; Savov, Valentin A. ; Georgieva, Elena I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-7542961ce5ced978ee22e0efb29c15609866ff634bab2c42adf2f92102c00fba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Alkanes - metabolism</topic><topic>Alkanes - pharmacology</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Candida</topic><topic>Candida - drug effects</topic><topic>Candida - enzymology</topic><topic>Candida - growth & development</topic><topic>Candida lipolytica</topic><topic>Catalase</topic><topic>Catalase - biosynthesis</topic><topic>Enzymes and enzyme inhibitors</topic><topic>Free Radicals</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose - pharmacology</topic><topic>N-Alkanes</topic><topic>Oxidation</topic><topic>Oxidation-Reduction</topic><topic>Superoxide Dismutase</topic><topic>Superoxide Dismutase - antagonists & inhibitors</topic><topic>Superoxide Dismutase - biosynthesis</topic><topic>Superoxide Dismutase - physiology</topic><topic>Superoxides - pharmacology</topic><topic>Yeast</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kujumdzieva-Savova, Anna V.</creatorcontrib><creatorcontrib>Savov, Valentin A.</creatorcontrib><creatorcontrib>Georgieva, Elena I.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Free radical biology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kujumdzieva-Savova, Anna V.</au><au>Savov, Valentin A.</au><au>Georgieva, Elena I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of superoxide dismutase in the oxidation of N-alkanes by yeasts</atitle><jtitle>Free radical biology & medicine</jtitle><addtitle>Free Radic Biol Med</addtitle><date>1991</date><risdate>1991</risdate><volume>11</volume><issue>3</issue><spage>263</spage><epage>268</epage><pages>263-268</pages><issn>0891-5849</issn><eissn>1873-4596</eissn><coden>FRBMEH</coden><abstract>Yeast microorganisms from
Candida genus are investigated for their superoxide dismutase (SOD) and catalase activity during cultivation on
N-alkanes. The later caused a considerable increase of Cu/Zn SOD activity of yeast cells in comparison with glucose. A correlation between SOD and catalase activity existed. It is further observed that cells of
Candida lipolytica 68–72 which contain a high level of Cu/Zn SOD were more resistant to lethality of exogenous O
2
−. An over-production of Cu/Zn SOD during the assimilation of
N-alkanes by yeasts is also connected to their considerable resistance to increased concentrations of Cu
2+ and Zn
2+ ions in the nutrient medium. The results are consistent with the assumption that the enhanced resistance of yeast cells to O
2
− and high concentrations of Cu
2+ and Zn
2+-ions are due to the increased activity of Cu/Zn SOD and that SOD is involved in the protection of some cellular components.
Polyacrylamide gel electrophoresis of
Candida lipolutica cell-free extracts revealed the same chromatic bands of SOD activity under growth on glucose and
N-alkanes. The type of the carbon source used from yeast cells as a single source of carbon and energy had no influence on the SOD profile of the cell.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1657738</pmid><doi>10.1016/0891-5849(91)90122-J</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Free radical biology & medicine, 1991, Vol.11 (3), p.263-268 |
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| subjects | Alkanes - metabolism Alkanes - pharmacology Analytical, structural and metabolic biochemistry Biological and medical sciences Candida Candida - drug effects Candida - enzymology Candida - growth & development Candida lipolytica Catalase Catalase - biosynthesis Enzymes and enzyme inhibitors Free Radicals Fundamental and applied biological sciences. Psychology Glucose - pharmacology N-Alkanes Oxidation Oxidation-Reduction Superoxide Dismutase Superoxide Dismutase - antagonists & inhibitors Superoxide Dismutase - biosynthesis Superoxide Dismutase - physiology Superoxides - pharmacology Yeast |
| title | Role of superoxide dismutase in the oxidation of N-alkanes by yeasts |
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