Delayed application of MK-801 attenuates development of morphine tolerance in rats
To investigate the possible involvement of enduring or delayed changes at the N-methyl- d-aspartic acid (NMDA) receptor in the mechanisms of morphine tolerance, rats were treated with the specific NMDA receptor antagonist, MK-801 (0.15 mg/kg) 2 h after morphine injection (20 mg/kg) during a 4-day in...
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| Veröffentlicht in: | Brain research 1991-08, Vol.558 (1), p.163-165 |
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| container_title | Brain research |
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| creator | Marek, Przemyslaw Ben-Eliyahu, Shamgar Vaccarino, Anthony L. Liebeskind, John C. |
| description | To investigate the possible involvement of enduring or delayed changes at the
N-methyl-
d-aspartic acid (NMDA) receptor in the mechanisms of morphine tolerance, rats were treated with the specific NMDA receptor antagonist, MK-801 (0.15 mg/kg) 2 h after morphine injection (20 mg/kg) during a 4-day induction period of tolerance. On the fifth day rats were injected only with morphine (15 mg/kg), and analgesia was assessed using the hot-plate test. Morphine tolerance was significantly reduced by MK-801. These findings suggest that long-lasting or delayed changes at the NMDA receptor underlie the development of morphine tolerance Moreover, because MK-801 was delivered 2 h after morphine and therefore could not serve as a cue for morphine administration, these findings indicate that the attenuating effect of MK-801 on the development of morphine tolerance is not attributable to state-dependent learning. |
| doi_str_mv | 10.1016/0006-8993(91)90736-F |
| format | Article |
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These findings suggest that long-lasting or delayed changes at the NMDA receptor underlie the development of morphine tolerance Moreover, because MK-801 was delivered 2 h after morphine and therefore could not serve as a cue for morphine administration, these findings indicate that the attenuating effect of MK-801 on the development of morphine tolerance is not attributable to state-dependent learning.</description><subject>Analgesia</subject><subject>Analgesics</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Dizocilpine Maleate - pharmacology</subject><subject>Drug Tolerance</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MK-801</subject><subject>Morphine</subject><subject>Morphine - pharmacology</subject><subject>N-Methyl- d-aspartic acid</subject><subject>Neuropharmacology</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>State-dependent learning</topic><topic>Time Factors</topic><topic>Tolerance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marek, Przemyslaw</creatorcontrib><creatorcontrib>Ben-Eliyahu, Shamgar</creatorcontrib><creatorcontrib>Vaccarino, Anthony L.</creatorcontrib><creatorcontrib>Liebeskind, John C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marek, Przemyslaw</au><au>Ben-Eliyahu, Shamgar</au><au>Vaccarino, Anthony L.</au><au>Liebeskind, John C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Delayed application of MK-801 attenuates development of morphine tolerance in rats</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1991-08-30</date><risdate>1991</risdate><volume>558</volume><issue>1</issue><spage>163</spage><epage>165</epage><pages>163-165</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>To investigate the possible involvement of enduring or delayed changes at the
N-methyl-
d-aspartic acid (NMDA) receptor in the mechanisms of morphine tolerance, rats were treated with the specific NMDA receptor antagonist, MK-801 (0.15 mg/kg) 2 h after morphine injection (20 mg/kg) during a 4-day induction period of tolerance. On the fifth day rats were injected only with morphine (15 mg/kg), and analgesia was assessed using the hot-plate test. Morphine tolerance was significantly reduced by MK-801. These findings suggest that long-lasting or delayed changes at the NMDA receptor underlie the development of morphine tolerance Moreover, because MK-801 was delivered 2 h after morphine and therefore could not serve as a cue for morphine administration, these findings indicate that the attenuating effect of MK-801 on the development of morphine tolerance is not attributable to state-dependent learning.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>1933379</pmid><doi>10.1016/0006-8993(91)90736-F</doi><tpages>3</tpages></addata></record> |
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| ispartof | Brain research, 1991-08, Vol.558 (1), p.163-165 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Analgesia Analgesics Analysis of Variance Animals Biological and medical sciences Dizocilpine Maleate - pharmacology Drug Tolerance Male Medical sciences MK-801 Morphine Morphine - pharmacology N-Methyl- d-aspartic acid Neuropharmacology Pharmacology. Drug treatments Rats Rats, Inbred Strains State-dependent learning Time Factors Tolerance |
| title | Delayed application of MK-801 attenuates development of morphine tolerance in rats |
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