The ITI system in South Koreans and Iranians analysed by an improved classification procedure : distribution of alleles and description of new phenotypes
Phenotype and gene frequency distributions of the inter-alpha-trypsin inhibitor (ITI) system were analysed in populations from southern Korea and from Iran. The gene frequencies of the common alleles ITI*I and ITI*2 were 0.532 and 0.422, respectively, in southern Korea, and 0.612 and 0.354, respecti...
Gespeichert in:
| Veröffentlicht in: | Human genetics 1991-10, Vol.87 (6), p.677-679 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 679 |
|---|---|
| container_issue | 6 |
| container_start_page | 677 |
| container_title | Human genetics |
| container_volume | 87 |
| creator | VOGT, U CLEVE, H FARHUD, D. D GOEDDE, H. W |
| description | Phenotype and gene frequency distributions of the inter-alpha-trypsin inhibitor (ITI) system were analysed in populations from southern Korea and from Iran. The gene frequencies of the common alleles ITI*I and ITI*2 were 0.532 and 0.422, respectively, in southern Korea, and 0.612 and 0.354, respectively, in Iran. The postulated third allele, ITI*3, was found in the homozygous form. Gene frequencies of this rare allele were calculated to be 0.042 and 0.029 in Korea and Iran, respectively. Two additional rare alleles, ITI*4 and ITI*5, determine further phenotypes found in the population from Taejon (Korea) and Iran, respectively, in combination with the common ITI*2 allele. Gene frequencies of ITI*4 and ITI*5 were calculated to be 0.006 and 0.005, respectively. For phenotype classification, untreated sera were separated by isoelectric focusing (IEF) on polyacrylamide gels followed by immunoblotting. |
| doi_str_mv | 10.1007/BF00201724 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72444321</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72444321</sourcerecordid><originalsourceid>FETCH-LOGICAL-c301t-76a0f72179a2cec2ea690ccc43462d852e303ba73736ed82fc8079034b73dffc3</originalsourceid><addsrcrecordid>eNqFkT-P1DAQxS0EOpaDhh7JBaJACoztJM7SHScOVpxEwVJHjj3WGjl_8CSgfBS-LYYsXEk1M34_PVnvMfZUwCsBoF-_vQGQILQs77GdKJUshAR1n-1AlVDUWuiH7BHRVwBR7WV1wS6EFk1Tih37eTwhPxwPnFaasedh4J_HZT7xj2NCMxA3g-OHZIawHSauhI53a9556Kc0fs-njYYo-GDNHMaB51eLbknI33AXaE6hW_4Io-cmRoy4-Tokm8L0VxrwB59OOIzzOiE9Zg-8iYRPzvOSfbl5d7z-UNx-en-4vrotrAIxF7o24LUUem-kRSvR1Huw1paqrKVrKokKVGe00qpG10hvG9D7HEynlfPeqkv2YvPNv_62IM1tH8hijGbAcaE2p1rmSMV_QVFDmVuQGXy5gTaNRAl9O6XQm7S2AtrfhbV3hWX42dl16Xp0d-jWUNafn3VD1kSfq7CB_mFV1UioavULZomejg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16042012</pqid></control><display><type>article</type><title>The ITI system in South Koreans and Iranians analysed by an improved classification procedure : distribution of alleles and description of new phenotypes</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>VOGT, U ; CLEVE, H ; FARHUD, D. D ; GOEDDE, H. W</creator><creatorcontrib>VOGT, U ; CLEVE, H ; FARHUD, D. D ; GOEDDE, H. W</creatorcontrib><description>Phenotype and gene frequency distributions of the inter-alpha-trypsin inhibitor (ITI) system were analysed in populations from southern Korea and from Iran. The gene frequencies of the common alleles ITI*I and ITI*2 were 0.532 and 0.422, respectively, in southern Korea, and 0.612 and 0.354, respectively, in Iran. The postulated third allele, ITI*3, was found in the homozygous form. Gene frequencies of this rare allele were calculated to be 0.042 and 0.029 in Korea and Iran, respectively. Two additional rare alleles, ITI*4 and ITI*5, determine further phenotypes found in the population from Taejon (Korea) and Iran, respectively, in combination with the common ITI*2 allele. Gene frequencies of ITI*4 and ITI*5 were calculated to be 0.006 and 0.005, respectively. For phenotype classification, untreated sera were separated by isoelectric focusing (IEF) on polyacrylamide gels followed by immunoblotting.</description><identifier>ISSN: 0340-6717</identifier><identifier>EISSN: 1432-1203</identifier><identifier>DOI: 10.1007/BF00201724</identifier><identifier>PMID: 1718841</identifier><identifier>CODEN: HUGEDQ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Alpha-Globulins - classification ; Alpha-Globulins - genetics ; Biological and medical sciences ; Classical genetics, quantitative genetics, hybrids ; Fundamental and applied biological sciences. Psychology ; Gene Frequency ; genes ; Genetics of eukaryotes. Biological and molecular evolution ; Human ; Humans ; Iran ; Isoelectric Focusing ; Korea ; Phenotype ; population genetics ; Trypsin Inhibitors - classification ; Trypsin Inhibitors - genetics</subject><ispartof>Human genetics, 1991-10, Vol.87 (6), p.677-679</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5582056$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1718841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VOGT, U</creatorcontrib><creatorcontrib>CLEVE, H</creatorcontrib><creatorcontrib>FARHUD, D. D</creatorcontrib><creatorcontrib>GOEDDE, H. W</creatorcontrib><title>The ITI system in South Koreans and Iranians analysed by an improved classification procedure : distribution of alleles and description of new phenotypes</title><title>Human genetics</title><addtitle>Hum Genet</addtitle><description>Phenotype and gene frequency distributions of the inter-alpha-trypsin inhibitor (ITI) system were analysed in populations from southern Korea and from Iran. The gene frequencies of the common alleles ITI*I and ITI*2 were 0.532 and 0.422, respectively, in southern Korea, and 0.612 and 0.354, respectively, in Iran. The postulated third allele, ITI*3, was found in the homozygous form. Gene frequencies of this rare allele were calculated to be 0.042 and 0.029 in Korea and Iran, respectively. Two additional rare alleles, ITI*4 and ITI*5, determine further phenotypes found in the population from Taejon (Korea) and Iran, respectively, in combination with the common ITI*2 allele. Gene frequencies of ITI*4 and ITI*5 were calculated to be 0.006 and 0.005, respectively. For phenotype classification, untreated sera were separated by isoelectric focusing (IEF) on polyacrylamide gels followed by immunoblotting.</description><subject>Alpha-Globulins - classification</subject><subject>Alpha-Globulins - genetics</subject><subject>Biological and medical sciences</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Frequency</subject><subject>genes</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Human</subject><subject>Humans</subject><subject>Iran</subject><subject>Isoelectric Focusing</subject><subject>Korea</subject><subject>Phenotype</subject><subject>population genetics</subject><subject>Trypsin Inhibitors - classification</subject><subject>Trypsin Inhibitors - genetics</subject><issn>0340-6717</issn><issn>1432-1203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkT-P1DAQxS0EOpaDhh7JBaJACoztJM7SHScOVpxEwVJHjj3WGjl_8CSgfBS-LYYsXEk1M34_PVnvMfZUwCsBoF-_vQGQILQs77GdKJUshAR1n-1AlVDUWuiH7BHRVwBR7WV1wS6EFk1Tih37eTwhPxwPnFaasedh4J_HZT7xj2NCMxA3g-OHZIawHSauhI53a9556Kc0fs-njYYo-GDNHMaB51eLbknI33AXaE6hW_4Io-cmRoy4-Tokm8L0VxrwB59OOIzzOiE9Zg-8iYRPzvOSfbl5d7z-UNx-en-4vrotrAIxF7o24LUUem-kRSvR1Huw1paqrKVrKokKVGe00qpG10hvG9D7HEynlfPeqkv2YvPNv_62IM1tH8hijGbAcaE2p1rmSMV_QVFDmVuQGXy5gTaNRAl9O6XQm7S2AtrfhbV3hWX42dl16Xp0d-jWUNafn3VD1kSfq7CB_mFV1UioavULZomejg</recordid><startdate>19911001</startdate><enddate>19911001</enddate><creator>VOGT, U</creator><creator>CLEVE, H</creator><creator>FARHUD, D. D</creator><creator>GOEDDE, H. W</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T3</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19911001</creationdate><title>The ITI system in South Koreans and Iranians analysed by an improved classification procedure : distribution of alleles and description of new phenotypes</title><author>VOGT, U ; CLEVE, H ; FARHUD, D. D ; GOEDDE, H. W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-76a0f72179a2cec2ea690ccc43462d852e303ba73736ed82fc8079034b73dffc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Alpha-Globulins - classification</topic><topic>Alpha-Globulins - genetics</topic><topic>Biological and medical sciences</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Frequency</topic><topic>genes</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Human</topic><topic>Humans</topic><topic>Iran</topic><topic>Isoelectric Focusing</topic><topic>Korea</topic><topic>Phenotype</topic><topic>population genetics</topic><topic>Trypsin Inhibitors - classification</topic><topic>Trypsin Inhibitors - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VOGT, U</creatorcontrib><creatorcontrib>CLEVE, H</creatorcontrib><creatorcontrib>FARHUD, D. D</creatorcontrib><creatorcontrib>GOEDDE, H. W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Human Genome Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VOGT, U</au><au>CLEVE, H</au><au>FARHUD, D. D</au><au>GOEDDE, H. W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The ITI system in South Koreans and Iranians analysed by an improved classification procedure : distribution of alleles and description of new phenotypes</atitle><jtitle>Human genetics</jtitle><addtitle>Hum Genet</addtitle><date>1991-10-01</date><risdate>1991</risdate><volume>87</volume><issue>6</issue><spage>677</spage><epage>679</epage><pages>677-679</pages><issn>0340-6717</issn><eissn>1432-1203</eissn><coden>HUGEDQ</coden><abstract>Phenotype and gene frequency distributions of the inter-alpha-trypsin inhibitor (ITI) system were analysed in populations from southern Korea and from Iran. The gene frequencies of the common alleles ITI*I and ITI*2 were 0.532 and 0.422, respectively, in southern Korea, and 0.612 and 0.354, respectively, in Iran. The postulated third allele, ITI*3, was found in the homozygous form. Gene frequencies of this rare allele were calculated to be 0.042 and 0.029 in Korea and Iran, respectively. Two additional rare alleles, ITI*4 and ITI*5, determine further phenotypes found in the population from Taejon (Korea) and Iran, respectively, in combination with the common ITI*2 allele. Gene frequencies of ITI*4 and ITI*5 were calculated to be 0.006 and 0.005, respectively. For phenotype classification, untreated sera were separated by isoelectric focusing (IEF) on polyacrylamide gels followed by immunoblotting.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>1718841</pmid><doi>10.1007/BF00201724</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-6717 |
| ispartof | Human genetics, 1991-10, Vol.87 (6), p.677-679 |
| issn | 0340-6717 1432-1203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72444321 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Alpha-Globulins - classification Alpha-Globulins - genetics Biological and medical sciences Classical genetics, quantitative genetics, hybrids Fundamental and applied biological sciences. Psychology Gene Frequency genes Genetics of eukaryotes. Biological and molecular evolution Human Humans Iran Isoelectric Focusing Korea Phenotype population genetics Trypsin Inhibitors - classification Trypsin Inhibitors - genetics |
| title | The ITI system in South Koreans and Iranians analysed by an improved classification procedure : distribution of alleles and description of new phenotypes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T13%3A09%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20ITI%20system%20in%20South%20Koreans%20and%20Iranians%20analysed%20by%20an%20improved%20classification%20procedure%20:%20distribution%20of%20alleles%20and%20description%20of%20new%20phenotypes&rft.jtitle=Human%20genetics&rft.au=VOGT,%20U&rft.date=1991-10-01&rft.volume=87&rft.issue=6&rft.spage=677&rft.epage=679&rft.pages=677-679&rft.issn=0340-6717&rft.eissn=1432-1203&rft.coden=HUGEDQ&rft_id=info:doi/10.1007/BF00201724&rft_dat=%3Cproquest_cross%3E72444321%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16042012&rft_id=info:pmid/1718841&rfr_iscdi=true |