Pranlukast protects leukotriene C4- and D4-induced epithelial cell impairment of the nasal mucosa in vitro
To investigate the effect of pranlukast on leukotriene- induced airway mucosal epithelial dysfunction, samples of human nasal mucosa obtained during surgery for facial trauma were exposed to leukotriene C4 and/or D4 and observed on a TV screen magnified x 2,500. Leukotriene C4- and D4-induced ciliar...
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| Veröffentlicht in: | Life sciences (1973) 2000-10, Vol.67 (22), p.2767-2773 |
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| container_end_page | 2773 |
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| container_issue | 22 |
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| container_title | Life sciences (1973) |
| container_volume | 67 |
| creator | Hisamatsu, K Nakajima, M |
| description | To investigate the effect of pranlukast on leukotriene- induced airway mucosal epithelial dysfunction, samples of human nasal mucosa obtained during surgery for facial trauma were exposed to leukotriene C4 and/or D4 and observed on a TV screen magnified x 2,500. Leukotriene C4- and D4-induced ciliary inhibition and delayed mucosal surface alterations appeared several hours later. Pranlukast prevented both the mucosal epithelial cell dysfunction and the delayed epithelial cell alteration. |
| doi_str_mv | 10.1016/S0024-3205(00)00856-0 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 2000-10, Vol.67 (22), p.2767-2773 |
| issn | 0024-3205 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Cells, Cultured Chromones - pharmacology Cilia - drug effects Cilia - physiology Humans Kinetics Leukotriene Antagonists - pharmacology Leukotriene C4 - antagonists & inhibitors Leukotriene C4 - pharmacology Leukotriene D4 - antagonists & inhibitors Leukotriene D4 - pharmacology Male Nasal Mucosa - cytology Nasal Mucosa - drug effects Nasal Mucosa - physiology Time Factors |
| title | Pranlukast protects leukotriene C4- and D4-induced epithelial cell impairment of the nasal mucosa in vitro |
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