Mode of action of 2-(diethylamino)-7-ethoxychromone on human platelets

The in vitro effect of 2‐(diethylamino)‐7‐ethoxychromone (RC39XVIII) on human platelet aggregation induced by several agonists and on thromoboxane B2 formation, granule release and intracellular cAMP elevation has been studied. The chromone‐derivative exerts a dose‐dependent inhibitory effect on agg...

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Veröffentlicht in:	Cell biochemistry and function 1991-04, Vol.9 (2), p.79-85
Hauptverfasser:	Leoncini, Giuliana, Maresca, Mitzi, Colao, Clorinda, Buzzi, Enrica, Mazzei, Mauro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Adenylyl Cyclases - metabolism aggregation Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system cAMP accumulation chromone-derivative Chromones - pharmacology Colforsin - pharmacology Collagen - pharmacology Cyclic AMP - metabolism Humans Iloprost - pharmacology Medical sciences Pharmacology. Drug treatments Phosphoric Diester Hydrolases - metabolism Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology Platelets Prostaglandin Endoperoxides, Synthetic - pharmacology Thrombin - pharmacology Thromboxane A2 - metabolism TxB2 formation
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