Leukocyte Mitochondrial DNA A to G Polymorphism at 11084 is not a Risk Factor for Japanese Migraineurs
Mitochondrial dysfunction has been reported in patients with migraine. We investigated leukocyte mitochondrial DNA 11084 A to G polymorphism in 166 Japanese migraineurs and 483 Japanese controls. The migraine group consisted of 43 patients suffering from migraine with aura (MWA) and 123 from migrain...
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| Veröffentlicht in: | Cephalalgia 2001-12, Vol.21 (10), p.987-989 |
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| creator | Takeshima, T Fukuhara, Y Adachi, Y Ishizaki, K Kusumi, M Kowa, H Iigaya, M Sakai, F Nakashima, K |
| description | Mitochondrial dysfunction has been reported in patients with migraine. We investigated leukocyte mitochondrial DNA 11084 A to G polymorphism in 166 Japanese migraineurs and 483 Japanese controls. The migraine group consisted of 43 patients suffering from migraine with aura (MWA) and 123 from migraine without aura (MOA). The frequency of the transition was 7.2% (12/166) in the migraine group and 7.3% (35/483) in the controls. The frequency of the transition was 4.7% in MWA and 8.1% in MOA. There was no significant difference among the groups (chi-square test). The mitochondrial DNA 11084 A to G transition was more common in Japanese subjects than reported in Caucasians; however, this polymorphism is not a genetic risk factor for migraine in Japanese patients. |
| doi_str_mv | 10.1046/j.1468-2982.2001.00305.x |
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We investigated leukocyte mitochondrial DNA 11084 A to G polymorphism in 166 Japanese migraineurs and 483 Japanese controls. The migraine group consisted of 43 patients suffering from migraine with aura (MWA) and 123 from migraine without aura (MOA). The frequency of the transition was 7.2% (12/166) in the migraine group and 7.3% (35/483) in the controls. The frequency of the transition was 4.7% in MWA and 8.1% in MOA. There was no significant difference among the groups (chi-square test). 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We investigated leukocyte mitochondrial DNA 11084 A to G polymorphism in 166 Japanese migraineurs and 483 Japanese controls. The migraine group consisted of 43 patients suffering from migraine with aura (MWA) and 123 from migraine without aura (MOA). The frequency of the transition was 7.2% (12/166) in the migraine group and 7.3% (35/483) in the controls. The frequency of the transition was 4.7% in MWA and 8.1% in MOA. There was no significant difference among the groups (chi-square test). The mitochondrial DNA 11084 A to G transition was more common in Japanese subjects than reported in Caucasians; however, this polymorphism is not a genetic risk factor for migraine in Japanese patients.</description><subject>Adult</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>DNA, Mitochondrial</subject><subject>Female</subject><subject>Genetic study</subject><subject>Humans</subject><subject>Japan</subject><subject>Male</subject><subject>migraine</subject><subject>Migraine Disorders - epidemiology</subject><subject>Migraine Disorders - genetics</subject><subject>mitochondria</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>risk factor</subject><subject>Risk Factors</subject><issn>0333-1024</issn><issn>1468-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOwzAQRS0EouXxC8grdgnj2E7SBYuqlJcKVAjWluvY4JLExU4E_XsSWsESFqMZae69MzoIYQIxAZaeLWPC0jxKRnkSJwAkBqDA488dNPxZ7KIhUEojAgkboIMQlgDAU0j30YCQnNE8I0NkZrp9c2rdaHxnG6deXV14K0t8cT_GY9w4fIXnrlxXzq9ebaiwbDAhkDNsA65dgyV-tOENX0rVOI9NV7dyJWsd-sAXL22tWx-O0J6RZdDH236Ini-nT5PraPZwdTMZzyLFGPCIM5pBCklBCyDcEOAZ4wuT8pxxOkoZhbwYgU60yUyhRlyZwtAFUdRoCsVC00N0usldeffe6tCIygaly7L7yLVBZAljBDLohPlGqLwLwWsjVt5W0q8FAdEzFkvRoxQ9StEzFt-MxWdnPdneaBeVLn6NW6id4Hwj-LClXv87WEym8-tu6vx84w_yRYula33dMfv7sS807JiZ</recordid><startdate>200112</startdate><enddate>200112</enddate><creator>Takeshima, T</creator><creator>Fukuhara, Y</creator><creator>Adachi, Y</creator><creator>Ishizaki, K</creator><creator>Kusumi, M</creator><creator>Kowa, H</creator><creator>Iigaya, M</creator><creator>Sakai, F</creator><creator>Nakashima, K</creator><general>SAGE Publications</general><general>Blackwell Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200112</creationdate><title>Leukocyte Mitochondrial DNA A to G Polymorphism at 11084 is not a Risk Factor for Japanese Migraineurs</title><author>Takeshima, T ; Fukuhara, Y ; Adachi, Y ; Ishizaki, K ; Kusumi, M ; Kowa, H ; Iigaya, M ; Sakai, F ; Nakashima, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4405-54370602d3d015f105745bf658453964308d90e2ef7fdc95cfdf3b1c3fe30dbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>DNA, Mitochondrial</topic><topic>Female</topic><topic>Genetic study</topic><topic>Humans</topic><topic>Japan</topic><topic>Male</topic><topic>migraine</topic><topic>Migraine Disorders - epidemiology</topic><topic>Migraine Disorders - genetics</topic><topic>mitochondria</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>risk factor</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takeshima, T</creatorcontrib><creatorcontrib>Fukuhara, Y</creatorcontrib><creatorcontrib>Adachi, Y</creatorcontrib><creatorcontrib>Ishizaki, K</creatorcontrib><creatorcontrib>Kusumi, M</creatorcontrib><creatorcontrib>Kowa, H</creatorcontrib><creatorcontrib>Iigaya, M</creatorcontrib><creatorcontrib>Sakai, F</creatorcontrib><creatorcontrib>Nakashima, K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cephalalgia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Takeshima, T</au><au>Fukuhara, Y</au><au>Adachi, Y</au><au>Ishizaki, K</au><au>Kusumi, M</au><au>Kowa, H</au><au>Iigaya, M</au><au>Sakai, F</au><au>Nakashima, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leukocyte Mitochondrial DNA A to G Polymorphism at 11084 is not a Risk Factor for Japanese Migraineurs</atitle><jtitle>Cephalalgia</jtitle><addtitle>Cephalalgia</addtitle><date>2001-12</date><risdate>2001</risdate><volume>21</volume><issue>10</issue><spage>987</spage><epage>989</epage><pages>987-989</pages><issn>0333-1024</issn><eissn>1468-2982</eissn><abstract>Mitochondrial dysfunction has been reported in patients with migraine. We investigated leukocyte mitochondrial DNA 11084 A to G polymorphism in 166 Japanese migraineurs and 483 Japanese controls. The migraine group consisted of 43 patients suffering from migraine with aura (MWA) and 123 from migraine without aura (MOA). The frequency of the transition was 7.2% (12/166) in the migraine group and 7.3% (35/483) in the controls. The frequency of the transition was 4.7% in MWA and 8.1% in MOA. There was no significant difference among the groups (chi-square test). The mitochondrial DNA 11084 A to G transition was more common in Japanese subjects than reported in Caucasians; however, this polymorphism is not a genetic risk factor for migraine in Japanese patients.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>11843871</pmid><doi>10.1046/j.1468-2982.2001.00305.x</doi><tpages>3</tpages></addata></record> |
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| subjects | Adult Asian Continental Ancestry Group - genetics DNA, Mitochondrial Female Genetic study Humans Japan Male migraine Migraine Disorders - epidemiology Migraine Disorders - genetics mitochondria Polymerase Chain Reaction Polymorphism, Genetic Polymorphism, Restriction Fragment Length risk factor Risk Factors |
| title | Leukocyte Mitochondrial DNA A to G Polymorphism at 11084 is not a Risk Factor for Japanese Migraineurs |
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