Insular cortex abnormalities in schizophrenia: a structural magnetic resonance imaging study of first-episode patients
The insular cortex is a limbic integration region that is engaged in emotional and cognitive functions. To investigate possible insular cortex abnormalities in schizophrenia, we measured insular gray matter volume and cortical surface size in drug-naive first-episode patients. Magnetic resonance ima...
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| Veröffentlicht in: | Schizophrenia research 2000-11, Vol.46 (1), p.35-43 |
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| creator | Crespo-Facorro, Benedicto Kim, Jae-Jin Andreasen, Nancy C. O'Leary, Daniel S. Bockholt, H.Jeremy Magnotta, Vincent |
| description | The insular cortex is a limbic integration region that is engaged in emotional and cognitive functions. To investigate possible insular cortex abnormalities in schizophrenia, we measured insular gray matter volume and cortical surface size in drug-naive first-episode patients. Magnetic resonance images were used to explore the morphology of the insular cortex of 25 healthy male volunteers, and 25 male schizophrenic patients. Groups were matched for age, sex, height, and parental socio-economic status. Clinical dimension scores were correlated with insular gray matter volume and cortical surface area.
Patients had a significant reduction in cortical surface area [patients=2020 (206); controls=2142 (204);
F=5.83, df=1,47;
P=0.01] and gray matter volume [patients=8.12 (0.77); controls=8.57 (0.94);
F=3.93, df=1,47;
P=0.05] in the left insular cortex. Insular gray matter volume and cortical surface size correlated negatively and significantly with the psychotic symptom dimension. Schizophrenic patients show morphological abnormalities in the insular cortex at early stages of the illness. These abnormalities are related to the severity of psychotic symptoms. Further investigations are needed to evaluate the role of the insula in the pathophysiology of schizophrenia. |
| doi_str_mv | 10.1016/S0920-9964(00)00028-1 |
| format | Article |
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Patients had a significant reduction in cortical surface area [patients=2020 (206); controls=2142 (204);
F=5.83, df=1,47;
P=0.01] and gray matter volume [patients=8.12 (0.77); controls=8.57 (0.94);
F=3.93, df=1,47;
P=0.05] in the left insular cortex. Insular gray matter volume and cortical surface size correlated negatively and significantly with the psychotic symptom dimension. Schizophrenic patients show morphological abnormalities in the insular cortex at early stages of the illness. These abnormalities are related to the severity of psychotic symptoms. Further investigations are needed to evaluate the role of the insula in the pathophysiology of schizophrenia.</description><identifier>ISSN: 0920-9964</identifier><identifier>EISSN: 1573-2509</identifier><identifier>DOI: 10.1016/S0920-9964(00)00028-1</identifier><identifier>PMID: 11099884</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Brain ; Cerebral Cortex - abnormalities ; Humans ; Insula ; Limbic system ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Psychotic symptoms ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenia - etiology ; Tomography</subject><ispartof>Schizophrenia research, 2000-11, Vol.46 (1), p.35-43</ispartof><rights>2000 Elsevier Science B.V.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-3157d48d6a0e02e1620bc20a51e259b69666ca68379f91d6f037038bf380ff983</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0920-9964(00)00028-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=830504$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11099884$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Crespo-Facorro, Benedicto</creatorcontrib><creatorcontrib>Kim, Jae-Jin</creatorcontrib><creatorcontrib>Andreasen, Nancy C.</creatorcontrib><creatorcontrib>O'Leary, Daniel S.</creatorcontrib><creatorcontrib>Bockholt, H.Jeremy</creatorcontrib><creatorcontrib>Magnotta, Vincent</creatorcontrib><title>Insular cortex abnormalities in schizophrenia: a structural magnetic resonance imaging study of first-episode patients</title><title>Schizophrenia research</title><addtitle>Schizophr Res</addtitle><description>The insular cortex is a limbic integration region that is engaged in emotional and cognitive functions. To investigate possible insular cortex abnormalities in schizophrenia, we measured insular gray matter volume and cortical surface size in drug-naive first-episode patients. Magnetic resonance images were used to explore the morphology of the insular cortex of 25 healthy male volunteers, and 25 male schizophrenic patients. Groups were matched for age, sex, height, and parental socio-economic status. Clinical dimension scores were correlated with insular gray matter volume and cortical surface area.
Patients had a significant reduction in cortical surface area [patients=2020 (206); controls=2142 (204);
F=5.83, df=1,47;
P=0.01] and gray matter volume [patients=8.12 (0.77); controls=8.57 (0.94);
F=3.93, df=1,47;
P=0.05] in the left insular cortex. Insular gray matter volume and cortical surface size correlated negatively and significantly with the psychotic symptom dimension. Schizophrenic patients show morphological abnormalities in the insular cortex at early stages of the illness. These abnormalities are related to the severity of psychotic symptoms. Further investigations are needed to evaluate the role of the insula in the pathophysiology of schizophrenia.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Cerebral Cortex - abnormalities</subject><subject>Humans</subject><subject>Insula</subject><subject>Limbic system</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Psychotic symptoms</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - etiology</subject><subject>Tomography</subject><issn>0920-9964</issn><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1rFTEQhoNY7LH6E5SAIHqxOtmP7KY3IkVtoeCFeh2y2Ukb2ZOsmWyx_fXm9BzqZa8Ghuedj4exVwI-CBDy4w9QNVRKyfYdwHsAqIdKPGEb0fVNVXegnrLNA3LMnhP9LpDooH_GjoUApYah3bCbi0DrbBK3MWX8y80YYtqa2WePxH3gZK_9XVyuEwZvTrnhlNNq85rMzLfmKmD2liekGEywyH3p-XBVqHW65dFx5xPlChdPcUK-mDI3ZHrBjpyZCV8e6gn79fXLz7Pz6vL7t4uzz5eVLYfmqinfTO0wSQMINQpZw2hrMJ3AulOjVFJKa-TQ9MopMUkHTQ_NMLpmAOfU0Jywt_u5S4p_VqSst54szrMJGFfSfd22IKApYLcHbYpECZ1eUvkl3WoBeidc3wvXO5saQN8L16LkXh8WrOMWp_-pg-ECvDkAhqyZXSqaPD1wQwMd7KhPewqLjBuPSZMtoixOPqHNeor-kUP-AaYKni0</recordid><startdate>20001130</startdate><enddate>20001130</enddate><creator>Crespo-Facorro, Benedicto</creator><creator>Kim, Jae-Jin</creator><creator>Andreasen, Nancy C.</creator><creator>O'Leary, Daniel S.</creator><creator>Bockholt, H.Jeremy</creator><creator>Magnotta, Vincent</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001130</creationdate><title>Insular cortex abnormalities in schizophrenia: a structural magnetic resonance imaging study of first-episode patients</title><author>Crespo-Facorro, Benedicto ; Kim, Jae-Jin ; Andreasen, Nancy C. ; O'Leary, Daniel S. ; Bockholt, H.Jeremy ; Magnotta, Vincent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-3157d48d6a0e02e1620bc20a51e259b69666ca68379f91d6f037038bf380ff983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Cerebral Cortex - abnormalities</topic><topic>Humans</topic><topic>Insula</topic><topic>Limbic system</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Psychotic symptoms</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - etiology</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Crespo-Facorro, Benedicto</creatorcontrib><creatorcontrib>Kim, Jae-Jin</creatorcontrib><creatorcontrib>Andreasen, Nancy C.</creatorcontrib><creatorcontrib>O'Leary, Daniel S.</creatorcontrib><creatorcontrib>Bockholt, H.Jeremy</creatorcontrib><creatorcontrib>Magnotta, Vincent</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Schizophrenia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crespo-Facorro, Benedicto</au><au>Kim, Jae-Jin</au><au>Andreasen, Nancy C.</au><au>O'Leary, Daniel S.</au><au>Bockholt, H.Jeremy</au><au>Magnotta, Vincent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insular cortex abnormalities in schizophrenia: a structural magnetic resonance imaging study of first-episode patients</atitle><jtitle>Schizophrenia research</jtitle><addtitle>Schizophr Res</addtitle><date>2000-11-30</date><risdate>2000</risdate><volume>46</volume><issue>1</issue><spage>35</spage><epage>43</epage><pages>35-43</pages><issn>0920-9964</issn><eissn>1573-2509</eissn><abstract>The insular cortex is a limbic integration region that is engaged in emotional and cognitive functions. To investigate possible insular cortex abnormalities in schizophrenia, we measured insular gray matter volume and cortical surface size in drug-naive first-episode patients. Magnetic resonance images were used to explore the morphology of the insular cortex of 25 healthy male volunteers, and 25 male schizophrenic patients. Groups were matched for age, sex, height, and parental socio-economic status. Clinical dimension scores were correlated with insular gray matter volume and cortical surface area.
Patients had a significant reduction in cortical surface area [patients=2020 (206); controls=2142 (204);
F=5.83, df=1,47;
P=0.01] and gray matter volume [patients=8.12 (0.77); controls=8.57 (0.94);
F=3.93, df=1,47;
P=0.05] in the left insular cortex. Insular gray matter volume and cortical surface size correlated negatively and significantly with the psychotic symptom dimension. Schizophrenic patients show morphological abnormalities in the insular cortex at early stages of the illness. These abnormalities are related to the severity of psychotic symptoms. Further investigations are needed to evaluate the role of the insula in the pathophysiology of schizophrenia.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>11099884</pmid><doi>10.1016/S0920-9964(00)00028-1</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Biological and medical sciences Brain Cerebral Cortex - abnormalities Humans Insula Limbic system Magnetic Resonance Imaging Male Medical sciences Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Psychotic symptoms Schizophrenia Schizophrenia - diagnosis Schizophrenia - etiology Tomography |
| title | Insular cortex abnormalities in schizophrenia: a structural magnetic resonance imaging study of first-episode patients |
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