Reduction of Cdc25A contributes to cyclin E1-Cdk2 inhibition at senescence in human mammary epithelial cells

Replicative senescence may be an important tumor suppressive mechanism for human cells. We investigated the mechanism of cell cycle arrest at senescence in human mammary epithelial cells (HMECs) that have undergone a period of 'self-selection', and as a consequence exhibit diminished p16IN...

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Veröffentlicht in:	Oncogene 2000-11, Vol.19 (47), p.5314-5323
Hauptverfasser:	SANDHU, Charanjit, DONOVAN, Jeffrey, BHATTACHARYA, Nandita, STAMPFER, Martha, WORLAND, Peter, SLINGERLAND, Joyce
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aging Amino Acid Sequence Biological and medical sciences Breast - cytology Breast cancer Cancer Carrier Proteins - metabolism CDC2-CDC28 Kinases cdc25 Phosphatases - genetics cdc25 Phosphatases - metabolism cdc25 Phosphatases - pharmacology Cdc25A pprotein Cdk2 protein Cell cycle Cell Cycle Proteins Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cells Cellular Senescence - drug effects Cellular Senescence - physiology Cyclin A Cyclin D1 Cyclin E Cyclin E - metabolism Cyclin-Dependent Kinase 2 Cyclin-dependent kinase 4 Cyclin-Dependent Kinase 6 Cyclin-Dependent Kinase Inhibitor p15 Cyclin-Dependent Kinase Inhibitor p16 Cyclin-Dependent Kinase Inhibitor p18 Cyclin-Dependent Kinase Inhibitor p19 Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p27 Cyclin-Dependent Kinases - antagonists & inhibitors Cyclin-Dependent Kinases - metabolism Cyclins - metabolism Ectopic expression Enzyme Inhibitors Epithelial cells Epithelial Cells - cytology Epithelial Cells - drug effects Female Fundamental and applied biological sciences. Psychology Fungal Proteins - metabolism Gene expression Genetic aspects Health sciences Humans Immortalization INK4a protein Kinases Kip protein Life span Mammary gland Medical research Microtubule-Associated Proteins - metabolism Molecular and cellular biology Molecular Motor Proteins Molecular Sequence Data p16 Protein Phase transitions Phosphatase Phosphorylation Physiological aspects Protein Kinase Inhibitors Protein kinases Protein-Serine-Threonine Kinases - metabolism Proteins Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Recombinant Fusion Proteins - pharmacology S phase Saccharomyces cerevisiae Proteins Senescence Tumor Cells, Cultured Tumor Suppressor Proteins Tumors
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