NATURAL KILLER CELLS ACTIVATE HUMAN DERMAL FIBROBLASTS

Human dermal fibroblasts (HDF) undergo activation and secrete cytokines when cocultured with T cells. Here, we identify potent activators of HDF among human peripheral CD2+-lymphocytes. Populations with strong HDF activating capacity consisted essentially of cells with a natural killer (NK) surface...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2000-12, Vol.12 (12), p.1755-1762
Hauptverfasser:	Müller, Kai M., Bickel, Matthias, Wiesmann, Ueli N., Spörri, Bernhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium - metabolism Calcium - pharmacology CD2 Antigens - metabolism CD3 Complex - metabolism CD4 Antigens - metabolism CD56 Antigen - metabolism CD8 Antigens - metabolism Cell Count Cell Division Cell Membrane - metabolism Chemokine CCL2 - metabolism chemokines/cytoplasmic free calcium/inflammation/dermal fibroblasts/lymphocytes Coculture Techniques Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay Fibroblasts - metabolism Flow Cytometry Humans Inflammation - metabolism Interleukin-1 - metabolism Interleukin-6 - metabolism Interleukin-8 - metabolism Killer Cells, Natural - metabolism Leukocytes, Mononuclear - metabolism Microscopy, Fluorescence Phenotype RNA - metabolism RNA, Messenger - metabolism Time Factors Up-Regulation
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