Involvement of the Ets-1 gene in overexpression of matrilysin in human hepatocellular carcinoma

Although matrix metalloproteinases (MMPs) are thought to be involved in the invasion and metastasis of a variety of malignant tumors, including human hepatocellular carcinoma (HCC), the mechanisms for the expression of MMPs in HCC are not known. To understand the mechanism(s) of MMP expression, the...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2000-11, Vol.60 (22), p.6519-6525
Hauptverfasser:	OZAKI, Iwata, MIZUTA, Toshihiko, GANG ZHAO, YOTSUMOTO, Hiroaki, HARA, Toshiya, KAJIHARA, Susumu, HISATOMI, Akitaka, SAKAI, Takahiro, YAMAMOTO, Kyosuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - genetics Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Down-Regulation Ets-1 gene Female Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans Liver Neoplasms - enzymology Liver Neoplasms - genetics Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Matrix Metalloproteinase 7 - biosynthesis Matrix Metalloproteinase 7 - genetics Medical sciences Middle Aged Molecular and cellular biology Oligonucleotides, Antisense - genetics Oligonucleotides, Antisense - pharmacology Promoter Regions, Genetic Proto-Oncogene Protein c-ets-1 Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-ets Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics Transcription Factors - biosynthesis Transcription Factors - genetics Transduction, Genetic Tumors
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