Carrier-mediated transport of riboflavin in the rat colon

Carriers involved in riboflavin transport have generally been presumed to be localized in the upper small intestine. However, using a closed loop technique, we found that in the rat colon the absorption of riboflavin could be significantly reduced by raising the concentration from 0.1 to 200 µM and...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 2000-03, Vol.21 (2), p.77-82
Hauptverfasser:	Yuasa, Hiroaki, Hirobe, Masato, Tomei, Shigemitsu, Watanabe, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Area Under Curve Biological and medical sciences Biological Transport - drug effects carrier-mediated transport colon Colon - drug effects Colon - metabolism Dose-Response Relationship, Drug Drug Carriers Flavins - pharmacology General and cellular metabolism. Vitamins Intestinal Absorption - drug effects Intestine, Small - drug effects Intestine, Small - metabolism Male Medical sciences Pharmacology. Drug treatments Photosensitizing Agents - pharmacokinetics rat Rats Rats, Wistar riboflavin Riboflavin - pharmacokinetics small intestine
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