Benzodiazepines act on GABAA receptors via two distinct and separable mechanisms

Benzodiazepines (BZs) act on γ-aminobutyric acid type A (GABA A ) receptors such as α 1 β 2 γ 2 through key residues within the N-terminal region of α subunits, to render their sedative and anxiolytic actions. However, the molecular mechanisms underlying the BZs' other clinical actions are not...

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Veröffentlicht in:	Nature neuroscience 2000-12, Vol.3 (12), p.1274-1281
Hauptverfasser:	Walters, Rhodri J., Hadley, Stephen H., Morris, Kendall D.W., Amin, Jahanshah
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Animal Genetics and Genomics Animals Behavioral Sciences Benzodiazepines Benzodiazepines - pharmacology Biological Techniques Biomedical and Life Sciences Biomedicine Control Diazepam - pharmacology Dosage and administration Dose-Response Relationship, Drug Flumazenil - pharmacology GABA gamma-Aminobutyric Acid - metabolism gamma-Aminobutyric Acid - pharmacology Membrane Potentials - drug effects Membrane Potentials - physiology Mutation Mutation - drug effects Mutation - physiology Neural transmission Neurobiology Neurosciences Oocytes - drug effects Oocytes - metabolism Physiological aspects Receptors Receptors, GABA-A - chemistry Receptors, GABA-A - drug effects Receptors, GABA-A - genetics Receptors, GABA-A - metabolism RNA, Messenger - metabolism Xenopus laevis Zinc - pharmacology
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