Intrinsic Fluorescence of the P-glycoprotein Multidrug Transporter:  Sensitivity of Tryptophan Residues to Binding of Drugs and Nucleotides

P-glycoprotein is a member of the ATP binding cassette family of membrane proteins, and acts as an ATP-driven efflux pump for a diverse group of hydrophobic drugs, natural products, and peptides. The side chains of aromatic amino acids have been proposed to play an important role in recognition and...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemistry (Easton) 2000-12, Vol.39 (48), p.14927-14938
Hauptverfasser:	Liu, Ronghua, Siemiarczuk, Aleksander, Sharom, Frances J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamide - pharmacology Amino Acid Sequence Animals ATP Binding Cassette Transporter, Subfamily B, Member 1 - chemistry ATP Binding Cassette Transporter, Subfamily B, Member 1 - drug effects Cricetinae Iodides - pharmacology Models, Molecular Molecular Sequence Data Nucleotides - metabolism Peptides - pharmacology Pharmaceutical Preparations Spectrometry, Fluorescence Tryptophan - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!