Imbalanced switch of the IGHG (immunoglobulin constant heavy G chain) Gm(bfn) genes in atopic childhood asthma

Background: The IGHG genes on chromosome 14q32, 5′μδγ3 γ1α1 γ2 γ4 εα2 3′, as studied by Gm allotypes, are involved in the inheritance of atopy. The 5′μδ b f α1 n γ4 εα2 3′, Gm(bfn) haplotype of the genetic B1‐cell variant has been found to be associated with the atopic phenotype of children with bro...

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