The Ubiquitin-Proteasome Pathway Mediates the Regulated Degradation of Mammalian 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase

3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR), the key regulatory enzyme in the mevalonate (MVA) pathway, is rapidly degraded in mammalian cells supplemented with sterols or MVA. This accelerated turnover was blocked byN-acetyl-leucyl-leucyl-norleucinal (ALLN), MG-132, and lactacystin, and...

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Veröffentlicht in:	The Journal of biological chemistry 2000-11, Vol.275 (46), p.35840-35847
Hauptverfasser:	Ravid, Tommer, Doolman, Ram, Avner, Rachel, Harats, Dror, Roitelman, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Galactosidase - genetics beta-Galactosidase - metabolism Bridged Bicyclo Compounds, Heterocyclic - pharmacology Cell Line Cholesterol - pharmacology Cricetinae Cycloheximide - pharmacology Cysteine Proteinase Inhibitors - pharmacology Farnesyl-Diphosphate Farnesyltransferase - antagonists & inhibitors Humans Hydroxycholesterols - pharmacology Hydroxymethylglutaryl CoA Reductases - metabolism Leupeptins - pharmacology Lovastatin - pharmacology Oligopeptides - pharmacology Peptide Hydrolases - metabolism Precipitin Tests Proteasome Endopeptidase Complex Recombinant Fusion Proteins - metabolism Tricarboxylic Acids - pharmacology Ubiquitins - metabolism
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