Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor

Growth of the human rhabdomyosarcoma A673 cell line in nude mice is substantially reduced but not completely suppressed after systemic administration of the antihuman vascular endothelial growth factor (VEGF) monoclonal antibody (Mab) A.4.6.1. Potentially, such escape might be attributable to incomp...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2000-11, Vol.60 (22), p.6253-6258
Hauptverfasser:	GERBER, Hans-Peter, KOWALSKI, Joe, SHERMAN, Daniel, EBERHARD, David A, FERRARA, Napoleone
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tumors. Experimental tumors Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacokinetics Antibodies, Monoclonal - pharmacology Biological and medical sciences Biological Availability Cell Division - physiology Endothelial Growth Factors - antagonists & inhibitors Endothelial Growth Factors - biosynthesis Endothelial Growth Factors - genetics Endothelial Growth Factors - immunology Experimental bone, joint and muscle tumors Gene Expression - drug effects Humans Immunoglobulin Fragments - immunology Immunoglobulin Fragments - metabolism Immunoglobulin Fragments - pharmacology Immunoglobulin G - immunology Immunoglobulin G - metabolism Immunoglobulin G - pharmacology Injections, Intralesional Lymphokines - antagonists & inhibitors Lymphokines - biosynthesis Lymphokines - genetics Lymphokines - immunology Medical sciences Mice Mice, Nude Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Proto-Oncogene Proteins - pharmacokinetics Proto-Oncogene Proteins - pharmacology Receptor Protein-Tyrosine Kinases - pharmacokinetics Receptor Protein-Tyrosine Kinases - pharmacology Reverse Transcriptase Polymerase Chain Reaction Rhabdomyosarcoma - blood supply Rhabdomyosarcoma - drug therapy Rhabdomyosarcoma - metabolism Rhabdomyosarcoma - pathology RNA - genetics RNA - metabolism Tumors Up-Regulation Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-1 Vascular Endothelial Growth Factors Xenograft Model Antitumor Assays
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